Regenerative Medicine Research

KEY FINDING: MRL/MpJ mice exhibit faster and more complete motor function recovery post-spinal cord injury compared to C57BL/6 mice.

KEY FINDING: Ibuprofen inhibits RhoA activation, enhancing axonal sprouting/regeneration.

KEY FINDING: Wnt gradients guide axons along the anterior-posterior axis in CNS development, as demonstrated by the role of Wnts in directing commissural axons in the spinal cord.

KEY FINDING: Notch pathway genes are upregulated after spinal lesion in specific dorsoventral domains around the ventricle, reflecting the dorsoventral polarity of the adult progenitor domains.

KEY FINDING: Cell-based therapies are emerging as promising therapeutic options for spinal cord regeneration and neuropathic pain mitigation after spinal cord injury.

KEY FINDING: EphrinB3 contributes significantly to the inhibitory activity of myelin, restricting neurite outgrowth of dorsal root ganglion cells in vitro.

KEY FINDING: PST-GFP SCs migrated significantly farther from the injury site compared to GFP SCs, extending up to 4.4 mm into the host tissue.

KEY FINDING: The described protocol permits conditional protein knockdown to examine the role of specific proteins during regenerative fin outgrowth.

KEY FINDING: Neurons derived from NRPs are intrinsically less sensitive to CSPGs, enabling them to extend axons across CSPG-rich areas.

KEY FINDING: Combining neurotrophic factors with cell transplantation can promote robust axonal growth into cellular transplants.