Spinal Cord Injury Research

KEY FINDING: TMEM176A and TMEM176B are significantly elevated in circulating monocytes from subjects with chronic SCI.

KEY FINDING: Mobility status significantly predicts falls; full-time wheelchair users are less likely to fall than full-time ambulators.

KEY FINDING: Females, younger persons, those with lower income, without paid work, more severe injuries, and longer time since injury were more often single.

KEY FINDING: A 26-year-old male sustained a complete spinal cord injury after diving headfirst into a foam pit at a trampoline park, despite the park having safety measures in place.

KEY FINDING: SCI+NP persons demonstrated increased parasympathetic tone (increased NN50, p=0.03, and pNN50, p=0.02, HRV parameters) following active BreEStim only.

KEY FINDING: A significant number of patients discharged on CIC stopped using it within 3 months due to lack of accessibility and financial support for catheters.

KEY FINDING: High-dose MP administration significantly reduced bone mineral density (BMD) in the distal femur and proximal tibia of SCI rats compared to SCI-vehicle animals.

KEY FINDING: A 58-year-old man developed complete paraplegia after a minor fall, with MRI suggesting longitudinally extensive transverse myelitis.

KEY FINDING: Wnt signaling, particularly the Wnt-Ryk pathway, inhibits axon regeneration after spinal cord injury, causing corticospinal tract axon retraction.

KEY FINDING: At the end of the training, all subjects learned to efficiently use the interface despite being compelled by it to engage their most impaired movements.