Browse the latest research summaries in the field of spinal disorders for spinal cord injury patients and caregivers.
Showing 81-90 of 104 results
Spinal Cord Series and Cases, 2015 • October 8, 2015
This study highlights the increasing prevalence of Charcot spinal arthropathy (CSA) in patients with spinal cord injuries (SCI). It emphasizes the importance of understanding initial symptoms, risk fa...
KEY FINDING: Charcot spinal arthropathy (CSA) is most likely increasing in patients suffering from consequences of spinal cord injury.
Neural Regeneration Research, 2015 • November 1, 2015
The study assessed the potential of diffusion tensor imaging (DTI) for quantitative assessment of compressed lumbosacral spinal nerve roots in patients with lumbosacral stenosis. DTI findings demonstr...
KEY FINDING: DTI showed thinning and distortion in 36 lumbosacral spinal nerve roots (49%) and abruption in 17 lumbosacral spinal nerve roots (23%) in patients with spinal stenosis.
ACS Nano, 2024 • January 18, 2024
The study introduces MnO2@TMNP, a novel nanomaterial designed to address disc degeneration and discogenic pain by targeting inflammation and promoting tissue regeneration. MnO2@TMNP's macrophage membr...
KEY FINDING: MnO2@TMNP effectively binds inflammatory factors and nerve growth factors, inhibiting inflammation-induced apoptosis and nerve ingrowth.
Neurospine, 2022 • September 1, 2022
This review aims to describe the involvement of ECM components in the remodeling process of spinal cord injury (SCI) and intervertebral disc degeneration (IVDD). SCI leads to damage to the intact ECM...
KEY FINDING: ECM components demonstrate both regenerative and degenerative potential in the central nervous system.
Eur Spine J, 2004 • August 14, 2003
This technical note presents a minimally invasive technique using topical rt-PA for evacuating extensive spinal subdural haematomas in two patients on long-term anticoagulation therapy. The technique ...
KEY FINDING: Topical application of rt-PA allows evacuation of the haematoma through a limited surgical exposure.
Aging and Disease, 2022 • April 1, 2022
This study investigates the role of CB2R in intervertebral disc degeneration (IVDD) by examining its effects on nucleus pulposus cell (NPC) senescence both in vitro and in vivo. The study found that C...
KEY FINDING: CB2R expression is decreased in degenerated nucleus pulposus (NP) tissues from both human IVDD patients and rat acupuncture IVDD models, while the expression of p16INK4a increased.
Oxidative Medicine and Cellular Longevity, 2021 • September 1, 2021
This study investigates the role of mitochondrial ROS in mechanical stress-induced disc degeneration using a one-strike loading organ culture model. The researchers found that mechanical stress leads ...
KEY FINDING: Mechanical stress induces mitochondrial dysfunction and ROS accumulation in nucleus pulposus (NP) cells. The proportion of ROS-positive cells increased significantly in the first 12 hours after mechanical stress.
Scientific Reports, 2025 • January 9, 2025
The study aimed to analyze cervical sagittal alignment changes following growing rod treatment in early-onset scoliosis (EOS) and identify risk factors for cervical imbalance using machine learning. T...
KEY FINDING: Growing rod surgery significantly affects cervical sagittal alignment in EOS patients.
Asian Spine J, 2016 • June 1, 2016
This retrospective study examined the influence of cervical spinal canal stenosis (CSCS) on neurological recovery after traumatic cervical spinal cord injury (CSCI) without major fracture or dislocati...
KEY FINDING: No significant relationships were found between the sagittal diameter of the cerebrospinal fluid (CSF) column at the C3–4 segment and the patients' motor scores at either admission or discharge.
Advanced Science, 2024 • December 25, 2023
The study developed LMGDNPs, injectable hydrogel microspheres, to address the nutrient imbalance and harsh microenvironment in degenerated intervertebral discs (IVD). LMGDNPs promoted cell survival an...
KEY FINDING: LMGDNPs showed a delayed release of lactate oxidase (LOX) and effectively consumed lactate, a harmful metabolic byproduct, creating a more favorable environment for cells.