Latest Research Summaries

KEY FINDING: Tamoxifen treatment decreased allodynia only in female rats with spinal cord injury, revealing a sex-dependent effect.

KEY FINDING: HGF-induced changes in gene expression were indicative of nerve regeneration and anti-inflammatory effects, in agreement with our earlier and simpler analysis of these RNA-seq data that then mostly neglected the time course of expression

KEY FINDING: Passive activity increased the number of volitional muscles that could be activated.

KEY FINDING: PEG-fusion repair reestablished axonal continuity after sciatic nerve injury in rats, leading to improved locomotor function compared to controls.

KEY FINDING: Liposomes enhance drug solubility, reduce toxicity, prolong half-life, and target specific ligands, making them effective in various fields.

KEY FINDING: Nanoparticles can effectively cross the blood-spinal cord barrier (BSCB), allowing drugs to reach the injury site more efficiently than traditional methods.

KEY FINDING: METTL14 expression in the locomotor cortex increases after spinal cord injury, along with elevated m6A levels.

KEY FINDING: The synergistic effect between anti-Nogo-A antibody and chondroitinase ABC (ChABC) enzyme resulted in superior outcomes, leading to enhanced sprouting and axon regeneration.

KEY FINDING: AA-NgR(310)ecto-Fc treatment in rats with chronic spinal contusion improved neurological recovery, particularly in open field locomotion, by increasing weight-bearing capacity and hindlimb foot movement.

KEY FINDING: Neural activity during sustained gestures shows a significant decrease in the ability to distinguish between different hand gestures held for more than 1 second.