Browse our collection of 11,526 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,951-3,960 of 11,526 results
Endocrine Connections, 2021 • October 22, 2021
This study investigates the evolutionary conservation and functional divergence of two homologous MC3Rs in the allotetraploid frog Xenopus laevis in vitro. The study clarified the interaction between ...
KEY FINDING: xlMRAP2.L/S enhances α-MSH-stimulated xlMC3Rs signaling and reduces their surface expression.
Neural Plasticity, 2021 • October 21, 2021
The analgesic mechanisms of SCS are gradually unveiled with the involvement of the “Gate control” theory, segmental inhibition, the descending inhibitory system, and cortical modulation. It is recomme...
KEY FINDING: SCS modulates nociceptive processing by inhibiting ascending nociceptive transmission via GABA and endocannabinoids, facilitating descending inhibition by releasing noradrenalin, dopamine, and serotonin, and activating supraspinal brain areas related to pain perception and emotion.
Frontiers in Neuroscience, 2021 • October 21, 2021
The study investigated the effects of tSCS and PNS on corticospinal excitability in healthy subjects using TMS. Three experiments were conducted to compare different stimulation parameters and their i...
KEY FINDING: Repeated pairing of TMS and tSCS, timed to coincide at the alpha-motoneurone, increases corticospinal excitability and influences functional motor output.
npj Regenerative Medicine, 2021 • October 21, 2021
This review summarizes the current progress of rehabilitative strategies in stem cell therapy for spinal cord injury. Regenerative rehabilitation is attracting wide attention owing to its synergistic ...
KEY FINDING: Regenerative rehabilitation can be categorized into conditioning/reconditioning, functional training, and physical exercise, which are indispensable for enhancing functional recovery achieved using stem cell therapies.
Global Advances in Health and Medicine, 2021 • October 21, 2021
This pilot study evaluated the feasibility and preliminary effectiveness of music-assisted relaxation (MAR), facilitated by a board-certified music therapist (MT-BC), for addressing pain and anxiety i...
KEY FINDING: VAS scores for pain significantly improved after both music therapy sessions (P ≤ .02).
Bioactive Materials, 2022 • October 20, 2021
This study presents a novel approach to spinal cord injury (SCI) repair by constructing a niche-specific spinal white matter-like tissue (WMLT) using decellularized optic nerve (DON) loaded with neuro...
KEY FINDING: The white matter-like tissue (WMLT) transplantation group showed significant improvement in coordinated motor functions compared with the control groups.
International Journal of Surgery Case Reports, 2021 • October 19, 2021
This case report describes the operative management of an 18-year-old male with a multilevel noncontiguous spinal fracture (MNSF) and spinal cord injury involving the cervical and thoracic vertebrae. ...
KEY FINDING: MNSF with spinal cord injury following high-velocity accidents are unstable and complex injuries.
eLife, 2021 • October 19, 2021
The study used functional MRI (fMRI) to investigate whether hand somatotopy is preserved in tetraplegic patients following a disconnect between the brain and the periphery. Results indicated that deta...
KEY FINDING: Somatotopic hand representations can be activated through attempted finger movements in tetraplegic patients even without sensory or motor hand function and no spared spinal tissue bridges.
Sensors, 2021 • October 18, 2021
This study presents a compact and lightweight hand exoskeleton designed to aid individuals with hand paralysis in regaining grasping functions. The device utilizes a three-layered sliding spring mecha...
KEY FINDING: The developed exoskeleton can produce a fingertip force of up to 8 N and cover 91.5 degrees of range of motion in just 3 seconds.
J NeuroEngineering Rehabil, 2021 • October 18, 2021
The study collates and synthesizes recommendations from multiple sources to create evidence-based guidelines for upper limb assessment in neurorehabilitation (CAULIN). The CAULIN recommendations defin...
KEY FINDING: The core set of recommended outcome measures includes the Fugl-Meyer Assessment of Upper Extremity (FMA-UE) and Action Research Arm Test (ARAT).