Browse our collection of 11,526 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,961-3,970 of 11,526 results
Neurochemical Research, 2022 • October 18, 2021
This study demonstrates that clemastine, a drug known to promote myelination, can enhance functional recovery in a rat model of spinal cord injury (SCI). The findings indicate that clemastine treatmen...
KEY FINDING: Clemastine treatment significantly improved motor function recovery in rats with SCI, as measured by BBB scoring, sloping board tests, and grid walking analysis.
Cells, 2021 • October 17, 2021
This review discusses the role of aldynoglia cells, particularly ependymocytes, tanycytes, and ependymal stem cells (EpSCs), in neuroinflammatory and neuroimmune responses following spinal cord injury...
KEY FINDING: Aldynoglia cells, including ependymocytes, tanycytes and ependymal stem cells, play a crucial role in the regeneration of spinal neural tissue after SCI.
International Journal of Surgery Case Reports, 2021 • October 16, 2021
This case report details the management of a 53-year-old male who sustained a thoracolumbar fracture-dislocation and a diaphragmatic hernia after a motorbike accident. The patient presented with parap...
KEY FINDING: The case demonstrates the rare co-occurrence of traumatic diaphragmatic hernia with thoracolumbar fracture-dislocation and spinal cord injury.
World Journal of Clinical Cases, 2021 • October 16, 2021
This case report describes a patient with complete SCI who experienced disruption of SDBE after an episode of bladder overdistension leading to AD. The patient, who had successfully used SDBE for 23 y...
KEY FINDING: Bladder overdistension in a patient with complete SCI disrupted a long-standing SDBE routine.
Cureus, 2021 • October 16, 2021
This study aimed to determine the pathoanatomy of CSM in patients and analyze the correlations between clinical key symptoms, myelopathic signs, and MRI findings. The MRI parameters such as canal and ...
KEY FINDING: The most common myelopathic signs observed were positive Hoffmann’s sign and the presence of reverse brachioradialis reflex.
Frontiers in Neurology, 2021 • October 15, 2021
The study quantifies upper extremity movement during a drinking task in individuals with SCI using 3D kinematic analysis. Key kinematic measures including movement time, smoothness, trunk displacement...
KEY FINDING: Individuals with limited upper extremity function after SCI showed impairments in movement time, smoothness, trunk displacement, and joint angles.
Frontiers in Cell and Developmental Biology, 2021 • October 15, 2021
The review highlights the complexity of the genetic system involved in central axon regeneration after SCI. Some genes active during development, such as KLF7, SOX11 and STAT3, are potential therapeut...
KEY FINDING: Corticospinal motor neurons (CSMNs) exhibit limited regeneration ability after spinal cord injury compared to other pathways in the central nervous system.
PLOS ONE, 2021 • October 14, 2021
This study investigated gene expression changes in the vastus lateralis muscle following different strength training regimes (CON/ECC+ and CON/ECC) during rehabilitation after ACL-R. The results indic...
KEY FINDING: Significant changes were detected in the expression of 26 mRNAs, several of them involved in muscle wasting/atrophy, indicating ongoing muscle remodeling processes.
NATURE COMMUNICATIONS, 2021 • October 14, 2021
The study addresses the divergence between embryonic development and adult regeneration in lizard tails, particularly concerning skeletal tissue patterning and dorsoventral organization. Researchers u...
KEY FINDING: Embryonic NSCs transplanted into adult ETs lose roof plate identity and are ventralized by the unchecked Hedgehog signaling of adult lizard tail environments.
AGING, 2021 • October 14, 2021
This study investigates the potential of resveratrol to improve function recovery after spinal cord injury (SCI) in rats. The researchers found that resveratrol promotes axonal regeneration, improves ...
KEY FINDING: Resveratrol significantly improved the function recovery, promoted axonal regeneration, suppressed apoptosis after SCI in rats.