Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 821-830 of 850 results
IEEE Trans Biomed Eng, 2013 • March 1, 2013
Paralysis has huge repercussions for individuals, families, and society, manifesting in various forms due to multiple disorders and affecting multiple body systems, with heterogeneity within patient g...
KEY FINDING: Electrical stimulation can be used to restore latent circuits or act as a neuroprosthetic intervention.
International Journal of Nanomedicine, 2023 • December 6, 2023
Spinal cord injury (SCI) treatment remains a significant clinical challenge, but neural tissue engineering offers a promising therapeutic approach through the implantation of functionalized electrocon...
KEY FINDING: Glial fibrosis and fluid-filled cysts impede electrical signaling and stimulus conduction in spinal cord tissue, hindering neural regeneration.
Materials Today Bio, 2024 • February 22, 2024
This study introduces an injectable nanocomposite hydrogel (OGPGM) composed of PGA-Mn nanoparticles, oxidized sodium alginate, and gelatin for treating osteoarthritis (OA). OGPGM exhibits excellent bi...
KEY FINDING: The nanocomposite hydrogel (OGPGM) exhibits excellent biocompatibility, effectively removes ROS from chondrocytes, and reduces inflammatory factors within the joint.
Top Spinal Cord Inj Rehabil, 2017 • April 1, 2017
The mobility applications of MEBot 2.0 – curb climbing/descending and attitude control – were introduced and evaluated through a stability analysis. The results showed that the position of the center ...
KEY FINDING: The area of the footprint changed with the location of the wheels during curb climbing/descending and attitude control applications.
J. Vis. Exp., 2012 • February 16, 2012
The spinal cordslice is an ideal recipient tissue for studying NPC ex vivo behaviours, post-transplantation, because the cytoarchitectonic tissue organization is well preserved within these cultures T...
KEY FINDING: NPCs showed highly directed cell migration towards the cathode when exposed to a range of physiological EFs.
Biomaterials, 2019 • April 1, 2019
This review comprehensively reports technologies related to ex vivo models and lab-on-a-chip devices used to model regeneration in the peripheral and central nervous systems. It discusses the necessit...
KEY FINDING: Animal models often fail in clinical trials due to differences in healing mechanisms, injury replicability, and biological mismatches between humans and animals.
Stem Cells International, 2015 • December 14, 2015
Spinal cord injury (SCI) is a central nervous system- (CNS-) related disorder for which there is yet no successful treatment. The roles of both cell- and biomaterial-based therapies as single therapeu...
KEY FINDING: Stem cells from different origins have been tested for their ability to stimulate nerve regeneration and restore the neuronal circuitry when integrated in the injured site.
Journal of Biomedical Materials Research Part A, 2018 • April 25, 2018
This study evaluates the effectiveness of a neurotrophin-3 (NT-3) releasing scaffold in treating spinal cord injury (SCI) in canines. The scaffold was designed to inhibit inflammation, promote nerve f...
KEY FINDING: The NT-3/fibroin scaffold (NF-GS) significantly improved hindlimb locomotion in canines with spinal cord injury compared to a control group (F-GS).
Biomedical Optics Express, 2011 • July 27, 2011
This study demonstrates the application of femtosecond lasers for precise ablation of melanocytes in Xenopus laevis tadpoles. It showcases the laser's ability to mark, pattern, and ablate these cells ...
KEY FINDING: Femtosecond lasers can be used to precisely ablate melanocytes in Xenopus laevis tadpoles, enabling controlled studies of cell migration and regeneration.
Med Eng Phys, 2014 • December 1, 2014
This study presents a novel framework for suppressing the effects of the involuntary background spikes by combining a Wiener filter [4] and a priori SNR estimation via the decision-directed method (us...
KEY FINDING: After the processing, the onset detection of voluntary muscle activity was significantly improved against involuntary background spikes.