Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 811-820 of 850 results
PLoS ONE, 2018 • February 22, 2018
This study presents the design and evaluation of a 3D-printed, open-source wrist-driven orthosis (WDO) for individuals with spinal cord injury (SCI). The aim was to improve the accessibility, customiz...
KEY FINDING: The 3D-printed WDO reduced hands-on assembly time to approximately 1.5 hours and the material costs to $15 compared to current fabrication methods.
Journal of Nanobiotechnology, 2022 • January 1, 2022
The study successfully developed a nanocomposite hydrogel with high conductivity, softness, biocompatibility, and anti-inflammatory properties for repairing spinal cord injuries (SCI). The composite h...
KEY FINDING: The MoS2/GO/PVA hydrogel exhibits excellent mechanical properties, outstanding electronic conductivity, and inflammation attenuation activity.
Langmuir, 2024 • December 9, 2024
This study introduces a computational framework to investigate the interactions between SAP fibrils and neuronal membranes using coarse-grained molecular dynamics simulations. The simulations reveal t...
KEY FINDING: LDLK3 monomers and AQP4 cause different structural perturbations in the neural membrane that may be interpreted as different lipid fingerprints.
Journal of Oral Biology and Craniofacial Research, 2017 • February 4, 2017
Stem cells possess self-renewal and differentiation capabilities, holding potential for treating various conditions, including tooth loss. Dental stem cells, easily accessible, offer promise in treati...
KEY FINDING: Dental stem cells are found in primary and permanent teeth, including wisdom teeth, making them a readily available resource.
J. Biomed. Opt., 2018 • June 29, 2018
This feasibility study investigated the use of live imaging to visualize neuronal fiber regeneration after spinal cord injury (SCI) and poly(lactide-co-glycolide) (PLG) bridge implantation in mice. Th...
KEY FINDING: Live imaging of neuronal fibers in the spinal cord of Thy1-eGFP mice is feasible both before and after SCI and PLG bridge implantation.
Nature Communications, 2018 • August 9, 2018
This work is based on the development of a biodegradable hybrid inorganic nanoscaffold and its utilization for the enhanced transplantation of stem cells into SCI sites. Our demonstrated nanoscaffold ...
KEY FINDING: The 3D-MnO2 nanoscaffolds can improve neuronal differentiation and neurite outgrowth, through the enhanced laminin binding and focal adhesion-related pathways.
International Journal of Nanomedicine, 2020 • January 27, 2020
The study explores the impact of graphene oxide nanoparticle (GO NP) size on mouse neural stem cell (mNSC) fate, including self-renewal and differentiation. Results showed that GO NPs generally exhibi...
KEY FINDING: GO NPs of all sizes showed low cytotoxicity at a concentration of 20 μg/mL on the mNSCs.
International Journal of Molecular Sciences, 2018 • August 22, 2018
The study evaluated three methacrylate hydrogels (HPMA, HEMA, and HEMA-Fn) as bridging scaffolds in a rat model of acute spinal cord injury (SCI). HPMA and HEMA-Fn hydrogels showed better bridging qua...
KEY FINDING: HPMA and HEMA-Fn hydrogels lead to partial sensory improvement compared to control animals and animals treated with plain HEMA scaffold.
Frontiers in Bioengineering and Biotechnology, 2021 • November 30, 2021
The study aimed to enhance the biological performance of 3D-printed Ti6Al4V implants by modifying their surface with a polydopamine (PDA) coating. In vitro results showed that the PDA coating improved...
KEY FINDING: PDA coating enhanced the hydrophilicity of 3D-printed Ti6Al4V implants.
Nature Communications, 2023 • October 27, 2023
This study introduces a 'psoriasis catalytic therapy' strategy using biomimetic materials (FeN4O2-SACs) to continuously scavenge overexpressed ROS, thereby ameliorating psoriatic lesions and preventin...
KEY FINDING: FeN4O2-SACs exhibit multiple enzyme-mimicking activities, analogous to natural antioxidant enzymes, demonstrating broad-spectrum ROS scavenging capability.