Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 831-840 of 850 results
Materials Today Bio, 2025 • February 3, 2025
This review discusses the use of hydrogels in spinal surgery for treating intervertebral disc degeneration, spinal cord injury, and dural injury, highlighting their potential for mechanical support an...
KEY FINDING: Hydrogels can provide mechanical support to the spine, fill defects, and facilitate localized drug delivery, enhancing therapeutic effects while reducing adverse reactions.
Bioactive Materials, 2022 • January 1, 2022
This study utilizes single-cell RNA sequencing to investigate the molecular mechanisms underlying MSC-mediated bone regeneration in different osteogenic microenvironments, specifically focusing on hyd...
KEY FINDING: HA scaffolds induce bone formation through a process similar to endochondral ossification, activating TGF-β, PTHrP, and BMP signaling pathways sequentially.
VIEW, 2022 • March 2, 2022
This study reveals that acidosis-related pH promotes SARS-CoV-2 infection by increasing ACE2 expression on the cell membrane, suggesting a positive feedback loop where SARS-CoV-2 infection-induced aci...
KEY FINDING: Acidosis-related pH (6.8) increases the expression of SARS-CoV-2 receptor ACE2 on the cell membrane.
International Journal of Nanomedicine, 2020 • January 21, 2020
The study aimed to enhance Schwann cell (SC) migration across astrocyte boundaries in vitro using chondroitinase ABC (ChABC)-loaded superparamagnetic nanoparticles (SPIONs) and a magnetic field (MF) t...
KEY FINDING: Magnetofection with ChABC/PEI-SPIONs significantly increased ChABC expression in SCs, which degrades chondroitin sulfate proteoglycans (CSPGs).
Journal of Nanobiotechnology, 2023 • January 1, 2023
This is a correction article for the original article which studies Acidic and hypoxic tumor microenvironment regulation by CaO(2)-loaded polydopamine nanoparticles. The correction addresses an error ...
KEY FINDING: The authors identified an error in affiliation in the original article.
Ann Transl Med, 2021 • July 1, 2021
This study investigated the effects of GelMA hydrogel on nerve repair and regeneration in mice with spinal cord injury (SCI). The results showed that GelMA hydrogel improved exercise ability, lengthen...
KEY FINDING: GelMA hydrogel improved exercise ability in mice with SCI. Mice treated with GelMA hydrogel had markedly higher total scores and sub-scores on the BMS compared to the model group.
PLoS ONE, 2013 • December 13, 2013
This study successfully isolated a recombinant antibody fragment (scFv) that binds to NCAM1-expressing cells in the intervertebral disc (IVD). This scFv has potential applications in targeted drug del...
KEY FINDING: A human scFv was successfully isolated against the recombinant NCAM1 domain using phage display technology.
Proc ASME Dyn Syst Control Conf, 2014 • October 1, 2014
This paper presents the performance characterization of the MAHI Exo-II, an upper extremity exoskeleton for stroke and spinal cord injury (SCI) rehabilitation, as a means to validate its clinical impl...
KEY FINDING: The MAHI Exo-II exhibits favorable static friction characteristics, both in magnitude and as a percentage of maximum continuous torque output.
International Journal of Nanomedicine, 2020 • January 1, 2020
The study investigated the interaction between MSCs and CP in a rat stroke model, finding that MSCs migrate to the CP and enhance its proliferation. MRI reveals MSC migration towards the CP in an isch...
KEY FINDING: ION-labeled MSCs migrate to the CP in an ischemic stroke model, as revealed by MRI and histological analysis.
Int. J. Mol. Sci., 2022 • December 28, 2021
This study aimed to enhance rhBMP-2-mediated regeneration of critical sized segmental bone defects using a biomimetic silk fibroin scaffold. The scaffold was designed with anisotropic channel-like por...
KEY FINDING: Highly porous, anisotropic silk scaffolds were successfully produced and demonstrated good cytocompatibility in vitro.