Cardiovascular Science Research

KEY FINDING: VEGF Trap treatment did not alter total vascularity in the injury epicenter or penumbral zones, suggesting that VEGF is not essential for SCI-induced neovascularization.

KEY FINDING: Dyslipidemia was present in 39.5% of the men with chronic SCI.

KEY FINDING: Cd9 and Mylip genes were identified as differentially expressed at 3 and 7 days post-injury (dpi) in a mouse contusion model of spinal cord injury.

KEY FINDING: The patient experienced frequent syncopal events with low blood pressure, despite initial treatment for orthostatic hypotension.

KEY FINDING: Spinal cord injury (SCI) triggers the mobilization of bone marrow-derived endothelial progenitor cells (EPCs), leading to a higher count of EPCs in the peripheral blood of patients within 7 days post-injury.

KEY FINDING: Pericytes are essential for maintaining the integrity of the spinal cord vasculature after SCI by providing neuroprotection, maintaining stem cell pluripotency, and promoting angiogenesis and vessel maturation.

KEY FINDING: The CMS hazards of overweight/obesity, insulin resistance, hypertension, and dyslipidemia are strongly associated with physical deconditioning and are common after SCI.

KEY FINDING: Updated guidelines suggest a broader MAP target range of 75–80 mmHg as the lower limit and 90–95 mmHg as the upper limit for 3–7 days of treatment post-SCI.

KEY FINDING: IVC filters, while intended to prevent pulmonary embolism, do not address the underlying thrombotic process and can potentially contribute to thrombosis.

KEY FINDING: Intravenous administration of RIPCs was most effective in reducing thermal hyperalgesia and mechanical allodynia in rats with neuropathic pain.