Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 291-300 of 1,651 results
Physiol Rep, 2018 • January 1, 2018
This study elucidates the mechanisms by which nandrolone stimulates the differentiation of myogenic lineage cells, focusing on the roles of MyoD and Numb. The research demonstrates that androgens stim...
KEY FINDING: Nandrolone increases both MyoD mRNA and protein expression in C2C12 myoblasts, indicating an upregulation of MyoD production.
Int. J. Mol. Sci., 2023 • October 31, 2023
This study aimed to induce neuronal features in adult canine dermal fibroblasts (ACDFs) using small molecules (SMs) and to assess the permanency of these changes, addressing the need for efficient neu...
KEY FINDING: Adult canine dermal fibroblasts (ACDFs) treated with eight small molecules (SMs) developed neuron-like morphology, including a round-shaped cell body with branching processes.
J South Med Univ, 2018 • February 1, 2018
This study compared the clinical efficacy of intramedullary and extramedullary decompression with lavage therapy versus extramedullary decompression alone for chronic cervical spinal cord injury. The ...
KEY FINDING: Patients undergoing intramedullary and extramedullary decompression (Group B) showed significantly higher JOA scores and improvement rates compared to those undergoing extramedullary decompression alone (Group A).
Spinal Cord, 2018 • November 1, 2018
This report explores the relationship between circulating TG and HDL-C concentrations, and more specifically, the serum TG concentrations at which serum HDL-C equals 40 mg/dl in SCI cohorts that are a...
KEY FINDING: The serum TG concentration that intersects with a serum HDL-C of 40 mg/dl is lower in persons with SCI than in the general population.
Neural Regeneration Research, 2018 • October 1, 2018
Depression is a significant long-term complication of traumatic brain injury (TBI) that can impair cognitive function and overall quality of life. The underlying cause of this increased depression ris...
KEY FINDING: TBI-induced inflammation, characterized by elevated cytokines, is a potential mechanism for post-TBI depression.
Journal of Neuroinflammation, 2018 • September 6, 2018
This study investigated the role of macrophage migration inhibitory factor (MIF) in the production of chemokine (C-C motif) ligand 5 (CCL5) in astrocytes following rat spinal cord injury. The results ...
KEY FINDING: CCL5 protein levels were increased in astrocytes of rat injured spinal cord, in parallel with the expression of MIF.
Biotechnol Bioeng, 2019 • January 1, 2019
This study investigated the ability of noggin and PDGF, individually or in combination, to enhance myelination of regenerating axons after spinal cord injury (SCI). Lentiviral vectors encoding noggin ...
KEY FINDING: The combination of noggin + PDGF enhanced total myelination of regenerating axons relative to either factor alone.
Neural Regeneration Research, 2018 • November 1, 2018
This study investigated the relationship between GFAP/S100B markers post-SCI and the global histone H4 acetylation levels. Results indicate global histone H4 acetylation levels exhibit a complex patte...
KEY FINDING: GFAP, but not S100B, was associated with global histone H4 acetylation levels after SCI.
Physiol Rep, 2018 • September 1, 2018
This study investigates the effects of myostatin on insulin action and glucose uptake in C2C12 muscle cells. Myostatin, known for its role in inhibiting muscle growth, is shown to impair insulin-stimu...
KEY FINDING: Myostatin significantly reduced basal and insulin-induced IRS-1 tyrosine phosphorylation, expression and activation of PI3K, associated with diminished AKT phosphorylation and elevated GSK3b phosphorylation.
Scientific Reports, 2018 • October 5, 2018
This study explored methods to enhance the recovery of cells expressing OEC marker p75NTR from rat mucosa. Key bioprocessing fundamentals were identified that will underpin future development of OEC-b...
KEY FINDING: A 24-hour differential adhesion step significantly increased the expression of p75NTR, an OEC marker, to 73 ± 5% and 46 ± 18% on PDL and laminin matrices, respectively.