Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 281-290 of 1,651 results
Mol Cell Neurosci, 2015 • September 1, 2015
This study identifies HHEX as a suppressor of axon growth when overexpressed in CNS neurons, acting through transcriptional repression to reduce axon initiation and extension without affecting cell vi...
KEY FINDING: HHEX acts as a potent suppressor of axon growth when overexpressed in CNS neurons.
Oncotarget, 2015 • August 17, 2015
In the present study, we originally demonstrated that PRDX6 prevents from intensified clinical deficits, more extensive demyelination and neurodegeneration, heightened CNS inflammation and BBB disrupt...
KEY FINDING: PRDX6 transgenic (Tg) mice displayed a significant decrease in clinical severity and attenuated demyelination in EAE compared to wide type mice.
The Journal of Neuroscience, 2009 • April 29, 2009
This study demonstrates that α9 integrin expression promotes neurite outgrowth on tenascin-C (TN-C) both in vitro and in vivo, suggesting a potential therapeutic strategy for enhancing axon regenerati...
KEY FINDING: Expression of α9 integrin in PC12 cells and adult rat DRG neurons promotes extensive neurite outgrowth on tenascin-C in vitro.
Biochemistry and Biophysics Reports, 2017 • January 17, 2017
This study investigates the effects of myostatin and an ALK4/5/7 inhibitor (SB431542) on miRNA expression in differentiating C2C12 myoblasts to understand the regulation of muscle-specific and highly ...
KEY FINDING: Myostatin (1 µg/ml) reduced the expression of miR-1 and miR-133a at 1 day post-differentiation induction but not at 3 days.
Neural Regeneration Research, 2015 • July 1, 2015
This study investigates the expression of miR-124 after spinal cord injury in mice using in situ hybridization and quantitative RT-PCR. The findings indicate that miR-124 expression is significantly r...
KEY FINDING: miR-124 is mainly expressed in neurons throughout the brain and spinal cord of mice.
Spinal Cord, 2017 • December 1, 2017
This study aimed to determine clinical factors associated with plasma C-reactive protein (CRP) in persons with chronic spinal cord injury (SCI). In multivariable models, factors associated with a high...
KEY FINDING: Greater BMI was associated with higher CRP levels, even when accounting for body fat distribution.
BMC Pulmonary Medicine, 2017 • August 8, 2017
This study investigated the relationship between systemic inflammation and pulmonary function in individuals with chronic spinal cord injury (SCI). The results showed that higher levels of inflammator...
KEY FINDING: Plasma CRP and IL-6 were inversely associated with FEV1 and FVC in individuals with chronic SCI.
MOLECULAR MEDICINE REPORTS, 2017 • July 12, 2017
The study developed a novel method for isolating and purifying Schwann cells (SCs) from mature Rhesus monkey nerves using in vitro pre-degeneration. The method involves pre-degeneration of nerve expla...
KEY FINDING: In vitro pre-degeneration in a modified SC culture medium (SCCM) increased SC purity and yield from monkey peroneal nerves.
Nature Communications, 2017 • August 7, 2017
This study investigates how distal axon injury remodels synapses contacting injured neurons using a microfluidic approach to compartmentalize cultured neurons. The research demonstrates that axotomize...
KEY FINDING: Axotomy causes retrograde dendritic spine loss at directly injured pyramidal neurons followed by retrograde presynaptic hyper-excitability.
Pain, 2018 • February 1, 2018
This study demonstrates that voluntary exercise prior to I/R injury blocks the increase in muscle IL1β and subsequent pain-related behaviors, suggesting a protective effect against ischemic myalgia. T...
KEY FINDING: Voluntary exercise prior to ischemia/reperfusion injury (I/R) prevents injury-induced muscle IL1β upregulation and subsequent pain-related behaviors.