Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 81-90 of 1,651 results
Frontiers in Immunology, 2025 • January 15, 2025
This study demonstrates that low-level spinal cord injury (SCI) enhances lung inflammation and immune responses in mice exposed to lipopolysaccharide (LPS), mimicking a bacterial infection. SCI amplif...
KEY FINDING: Spinal cord injury (SCI) at the T9 level amplifies lung inflammation in mice following exposure to lipopolysaccharide (LPS), as evidenced by increased pro-inflammatory gene expression and cytokine release.
Journal of Neuroinflammation, 2025 • January 27, 2025
This study demonstrates a significant upregulation of C/EBPβ in microglia in a mouse model of SCI, suggesting its involvement in the post-SCI neuroinflammatory response. The research uncovers that C/E...
KEY FINDING: C/EBPβ is significantly upregulated in microglia after spinal cord injury in mice and is associated with neuroinflammation.
Neurochemical Research, 2025 • January 16, 2025
This study investigates the mechanisms underlying neuropathic pain (NP), focusing on the role of mTOR in astrocytes. It finds that mTOR is activated in astrocytes following chronic constriction injury...
KEY FINDING: mTOR is activated in astrocytes within the spinal cord following chronic constriction injury (CCI), contributing to neuropathic pain.
PLOS ONE, 2025 • February 27, 2025
This study investigated the role of anoikis-related genes in neuropathic pain (NP), particularly in lumbar disc herniation (LDH). Machine learning algorithms identified six key genes (HGF, MMP13, ABL1...
KEY FINDING: Six key anoikis-related genes (HGF, MMP13, ABL1, ELANE, FASN, and LINC00324) were identified as having diagnostic value for NP.
Journal of Neuroinflammation, 2025 • February 14, 2025
This study investigates the microglial response from subacute to chronic cervical SCI in rats, finding distinct microglial signatures that overlap between the subacute and chronic periods. The subacut...
KEY FINDING: Subacute SCI is characterized by a disease-associated microglial (DAM) signature, while chronic SCI is highly heterogeneous, with both injury-induced and homeostatic states.
CNS Neuroscience & Therapeutics, 2025 • March 5, 2025
This letter to the editor provides comments on a research article concerning the role of H4K12 lactylation in promoting Spp1 transcription and aiding functional recovery post-spinal cord injury (SCI)....
KEY FINDING: The original study demonstrated the significant role of recombinant Spp1 protein (rSPP1) in functional recovery after spinal cord injury.
The Journal of Spinal Cord Medicine, 2021 • January 1, 2021
This case report highlights a case of spinal cord infarction (SCI) in a young adult, emphasizing the role of genetic mutations in such events and the importance of early genetic testing. The study sug...
KEY FINDING: The patient had multiple heterozygous and homozygous gene mutations, including factor II G20210A, MTHFR A1298C, factor XIII, beta-fibrinogen, and ACE D-allele.
The Journal of Spinal Cord Medicine, 2021 • January 1, 2021
This study compared the effects of intensity-matched acute exercise on inflammatory markers between able-bodied (AB) and spinal cord injured (SCI) individuals. SCI individuals exhibited a consistently...
KEY FINDING: The SCI group had higher levels of interleukin-2 (IL-2) and lower levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) at all measurement times compared to the AB group.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
The study investigated the association between ibuprofen use and systemic inflammation markers (CRP and IL-6) in individuals with chronic SCI. Results indicated that ibuprofen use was associated with ...
KEY FINDING: Ibuprofen users had significantly lower CRP levels (2.3 mg/L versus 3.5 mg/L, P = 0.04) compared to nonusers after adjusting for clinical and demographic factors.
Neural Regen Res, 2021 • September 1, 2021
The study investigated the role of HMGB1 in the inflammatory response of astrocytes following spinal cord injury (SCI) in rats using transcriptome sequencing and in vitro experiments. The results show...
KEY FINDING: HMGB1/TLR4 axis is involved in astrocyte inflammatory response through regulation of COX2/PGE2 signaling.