Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 101-110 of 620 results
Journal of Neuroinflammation, 2019 • December 10, 2019
This study demonstrates that lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with SCI. The study shows that reducing α-synuclein pr...
KEY FINDING: Downregulation of α-synuclein reduces inflammatory infiltration and preserves myelin after SCI.
INTERNATIONAL JOURNAL OF MOlecular medicine, 2020 • January 31, 2020
The study aimed to evaluate the effect of the CX3CR1 inhibitor AZD8797 in early recovery after acute SCI and elucidate its potential mechanism in blocking inflammation and apoptosis. AZD8797 improved ...
KEY FINDING: CX3CR1 and CX3CL1 expression levels increase after spinal cord injury, peaking at 10 days, suggesting their involvement in the inflammatory response.
Journal of Neuroinflammation, 2020 • May 19, 2020
This review discusses the potential role of environmental factors, particularly nerve injury, in initiating and propagating ALS. Animal models demonstrate that nerve injury can accelerate disease prog...
KEY FINDING: Nerve injury can hasten functional decline and shorten survival in SOD1 rat models of ALS, suggesting injury can initiate earlier disease onset and promote local spread.
AGING, 2020 • June 9, 2020
This study investigates the role of Mlxipl in neuropathic pain (NP), focusing on its impact on neuroinflammation in the spinal dorsal horn (SDH) following peripheral nerve injury. The key findings dem...
KEY FINDING: Mlxipl expression is upregulated in the ipsilateral spinal dorsal horn (SDH) of rats with Spared Nerve Injury (SNI)-induced mechanical allodynia.
Cells, 2020 • June 8, 2020
This review discusses the neuropsychological abnormalities and pathophysiological alterations in the brain following SCI, including cognitive impairments and mood disturbances. Clinical evidence indic...
KEY FINDING: SCI patients are at a significantly higher risk for developing dementia, with some studies suggesting they are 13 times more likely to develop cognitive impairments.
eLife, 2020 • September 7, 2020
This study demonstrates evidence for a receptor-mediated signaling role for complement C1q in the CNS, modulating NSC migration, proliferation, and lineage commitment. The study defines and validates ...
KEY FINDING: C1q activates specific intracellular signaling pathways in NSC to modulate NSC behavior.
BMJ Open, 2020 • October 5, 2020
The RESCOM study is a prospective, international, multicentre cohort study designed to identify modifiable predictors of pneumonia in individuals with spinal cord injury (SCI) during inpatient rehabil...
KEY FINDING: The study aims to evaluate the ability of parameters of respiratory function to predict and understand variation in inpatient risk of pneumonia in SCI.
Scientific Reports, 2020 • November 13, 2020
This study investigated the impact of C6 deficiency on spinal cord injury (SCI) recovery in PVG rats, comparing outcomes between rats from separate homozygous colonies and littermate controls. The fin...
KEY FINDING: Rats maintained as separate homozygous colonies showed improved locomotor outcome with C6 deficiency, while littermate controls exhibited impaired locomotor outcome with C6 deficiency.
Front. Syst. Neurosci., 2020 • October 15, 2020
This case report investigates the effects of prolonged cardiovascular-targeted epidural stimulation (CV-scES) on cardiovascular function and immune system modulation in an individual with chronic cerv...
KEY FINDING: Orthostatic tolerance improved significantly, from 10 minutes pre-CV-scES to the full 30 minutes post-CV-scES during a head-up tilt test.
Spinal Cord Series and Cases, 2020 • October 7, 2020
This case report describes a rare instance of a spinal epidural abscess (SEA) secondary to septic arthritis of a thoracic facet joint (SAFJ) in a 53-year-old woman, leading to spinal cord compression ...
KEY FINDING: Early diagnosis and treatment of septic arthritis of the facet joint and spinal epidural abscess are crucial to prevent severe neurological consequences.