Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 451-460 of 620 results
Dermatol Ther (Heidelb), 2025 • January 24, 2025
This study evaluated the rate of infections in patients with psoriasis and spinal cord injuries treated with systemic immunosuppressants over a 5-year period. The results showed that methotrexate was ...
KEY FINDING: Patients with SCI treated with MTX had higher infection rates compared to those treated with biologics.
Frontiers in Immunology, 2025 • January 9, 2025
This study explores the spatial dynamics of immune cells in spinal cord injury, highlighting their complex role in the recovery process. Immune cells not only contribute to healing and protecting the ...
KEY FINDING: The spatial dynamics of immune cells following SCI are crucial for understanding their mechanisms in neuroinflammation and repair, and for developing new therapies.
International Journal of Surgery Case Reports, 2025 • January 23, 2025
This case report presents a rare instance of urogenital myiasis in a 40-year-old male with a spinal cord injury and long-term indwelling urinary catheter, a combination not frequently reported in exis...
KEY FINDING: A 40-year-old male with a spinal cord injury developed urogenital myiasis due to long-term catheter use, presenting with maggots at the urethral meatus.
Journal of Neuroinflammation, 2025 • January 10, 2025
This study investigated the therapeutic potential of targeting Fidgetin-like 2 (FL2) after spinal cord injury (SCI) in rats. The researchers hypothesized that FL2 knockdown would increase the benefici...
KEY FINDING: SCI significantly increased FL2 expression in the lesion site and rostral to the lesion at 1 day post-injury.
Journal of Pain Research, 2025 • March 7, 2025
This study investigates the therapeutic effects of electroacupuncture (EA) on neuropathic pain (NP) in a rat model. The research focuses on the role of NLRP3 inflammasome-mediated pyroptosis in microg...
KEY FINDING: EA treatment significantly alleviated pain hypersensitivity by increasing the MWT and PWL in CCI rats.
Cureus, 2025 • March 20, 2025
This case series investigates the rapid reversal of forearm supinator rigidity using topical isomerized potassium linoleate (KCLA) in five patients diagnosed with vertigo of central origin. The study ...
KEY FINDING: Topical application of isomerized potassium linoleate (KCLA) rapidly reduced tenderness in the forearm supinator muscle within 2-4 minutes.
Bioelectronic Medicine, 2025 • March 6, 2025
The study investigated the effects of low-intensity trans-spinal focused ultrasound (tsFUS) on neuropathic pain in rats with chronic constriction injury (CCI). tsFUS was applied to the L5 spinal segme...
KEY FINDING: tsFUS treatment increased the von Frey threshold (vFT) in rats with CCI compared to sham treatment, indicating reduced mechanical sensitivity. This effect persisted for up to 23 days post-CCI.
Journal of Neurology, Neurosurgery, and Psychiatry, 1979 • January 1, 1979
The study examined the effect of induced immunological unresponsiveness to CNS antigens, alone and in conjunction with cyclophosphamide, on spinal cord regeneration in rats after complete spinal cord ...
KEY FINDING: Rats made immunologically unresponsive to CNS tissue alone did not show increased corticospinal regeneration as measured by axonal transport.
The Journal of Neuroscience, 1994 • October 1, 1994
This study explores the therapeutic potential of monoclonal autoantibodies in promoting CNS repair using a mouse model of multiple sclerosis. Monoclonal antibodies derived from mice injected with spin...
KEY FINDING: Monoclonal IgM autoantibodies SCH94.03 and SCH94.32 promoted significant CNS remyelination in mice chronically infected with TMEV compared to controls.
The Journal of Neuroscience, 1998 • October 1, 1998
This study demonstrates that oligodendrocyte-reactive IgMk mAbs promote remyelination in a virus model of MS, suggesting that targeting polyreactive Abs to oligodendrocytes can promote CNS remyelinati...
KEY FINDING: IgMk mAb SCH79.08, which binds to myelin basic protein, promotes CNS remyelination in TMEV-infected mice.