Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 461-470 of 620 results
Current Osteoporosis Reports, 2024 • January 10, 2024
OSM plays unique roles in regulating the maintenance and regeneration of bone, hematopoietic stem and progenitor cells, inflammation, and skeletal muscles. Dysregulated OSM production can lead to bone...
KEY FINDING: OSM regulates bone mass by stimulating osteoclast formation and promoting osteoblast commitment through the OSMR receptor.
Viruses, 2022 • March 18, 2022
The study investigated the dynamics of SARS-CoV-2 antibodies in Austrian blood donors one year after infection, evaluating the impact of various factors on antibody levels and functionality. Key findi...
KEY FINDING: Anti-N antibody levels decline over one year post-infection, while anti-S antibody levels remain stable.
CNS Drugs, 2011 • July 1, 2011
Repair of the central nervous system (CNS) constitutes the integral part in treating neurologic diseases and plays a crucial role in restoring CNS architecture and function. In this review, we discuss...
KEY FINDING: The major challenges of CNS repair include neurodegeneration and pathological obstacles impeding neural cell growth after CNS injury.
Current Topics in Microbiology and Immunology, 2008 • January 1, 2008
Promoting remyelination following injury to the central nervous system (CNS) promises to be an effective neuroprotective strategy to limit the loss of surviving axons and prevent disability. This revi...
KEY FINDING: A recombinant form of a human remyelination-promoting IgM (rHIgM22) targets areas of CNS injury and promotes maximal remyelination within 5 weeks after a single low dose (25 µg/kg).
Frontiers in Cellular and Infection Microbiology, 2024 • October 7, 2024
This study investigates the function of PfNSUN1, an RNA m5C methyltransferase, in Plasmodium falciparum. It demonstrates that PfNSUN1 is indispensable for parasite growth and development during the in...
KEY FINDING: PfNSUN1 is required for parasite development during the intraerythrocytic developmental cycle (IDC). Knockdown of PfNSUN1 resulted in a significant decrease in parasite growth efficiency.
Exp Neurol, 2014 • August 1, 2014
This review examines immune responses to spinal cord injury (SCI) in non-mammalian vertebrates, which often exhibit significant spontaneous recovery. Identifying the mechanisms behind their regenerati...
KEY FINDING: Lampreys, zebrafish, salamanders, frogs, and turtles exhibit axon regeneration after spinal cord injury, followed by a glial bridge formation.
J Neurochem, 2016 • September 1, 2016
Neuroinflammation plays a critical role in neurodegenerative diseases, making innate immune activation a promising therapeutic target. This mini review series originated from the 4th Venusberg Meeting...
KEY FINDING: Microglia, the brain's immune cells, have diverse morphologies and functions depending on their environment and stage of development.
J Neuropathol Exp Neurol, 1999 • January 1, 1999
The study compares Theiler's virus infection in class I and class II MHC-deficient mice. Class II-deficient mice develop paralysis and demyelination, whereas class I-deficient mice only develop demyel...
KEY FINDING: Class II-deficient mice showed minimal oligodendrocyte remyelination compared to class I-deficient mice, which demonstrated extensive remyelination.
Journal of Extracellular Vesicles, 2022 • March 2, 2022
This study investigates the functional role of the protein corona surrounding extracellular vesicles (EVs) derived from human placental-expanded (PLX) stromal cells. The researchers found that this co...
KEY FINDING: PLX-EVs are surrounded by a functional protein corona when enriched with permissive technology, containing immunomodulatory and proangiogenic proteins.
International Journal of Infectious Diseases, 2023 • January 10, 2023
This study comprehensively analyzed the prevalence, severity, and characteristics of smell and taste alterations (STAs) in patients infected with the SARS-CoV-2 Omicron variant. The findings suggest t...
KEY FINDING: The prevalence of smell and taste alterations did not significantly decrease during the Omicron dominance compared to earlier phases of the pandemic.