Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 471-480 of 620 results
J. Anat., 2009 • June 24, 2009
This study investigated the effect of cyclosporin A (CsA) on functional recovery and the cellular environment following spinal cord contusion injury in rats. CsA was administered to rats after a moder...
KEY FINDING: CsA treatment resulted in a short-term functional improvement at 3 weeks post-injury in the left hindlimbs of rats.
Journal of Neuroinflammation, 2016 • April 14, 2016
The study investigates the role of APRIL in fibrotic scar formation after SCI, finding that APRIL and BCMA expression increases following SCI. Genetic deletion of APRIL resulted in reduced fibrotic sc...
KEY FINDING: APRIL expression, along with its receptor BCMA, increases following spinal cord injury.
Journal of Neurology, Neurosurgery & Psychiatry, 1985 • January 1, 1985
The study aimed to determine if immunosuppressive treatment could facilitate spinal cord regeneration in rats after complete spinal cord transection, using cyclophosphamide and cyclosporin. The result...
KEY FINDING: Neither cyclosporin nor cyclophosphamide enhanced CNS regeneration in rats with complete spinal cord transection.
Nature Communications, 2020 • September 9, 2020
This study presents a pH-responsive immunomodulatory strategy for neural regeneration using electrospun fibers that release IL-4 plasmids to suppress inflammation and promote neural differentiation. T...
KEY FINDING: The microenvironment-responsive immunoregulatory electrospun fibers were able to shift immune cell subtypes to down-regulate the acute inflammation response.
Nucleic Acids Research, 2022 • March 14, 2022
This study systematically profiled the genome-wide occupancy of eighteen Apicomplexan AP2 transcription factors to identify and characterize eight heterochromatin-associated factors (PfAP2-HFs) in Pla...
KEY FINDING: Eight heterochromatin-associated ApiAP2 transcription factors (PfAP2-HFs) were identified, showing preferential enrichment within heterochromatic regions but with differential coverage profiles.
Journal of Neuroinflammation, 2016 • September 28, 2016
Post-SCI multiple organ dysfunction is influenced by multifactorial mechanisms, and the extent to which systemic inflammation and immune depression contribute to SCI-associated complications is still ...
KEY FINDING: SCI triggers systemic inflammatory responses, marked by increased immune cells and pro-inflammatory mediators, leading to inflammation in secondary organs.
Antibody Therapeutics, 2025 • December 16, 2024
This research describes the creation and characterization of humanized anti-CD11d monoclonal antibodies as potential therapeutics for inflammatory conditions. In vitro and in vivo studies demonstrated...
KEY FINDING: The researchers successfully developed and characterized five humanized anti-CD11d monoclonal antibodies.
Stem Cells International, 2021 • August 24, 2021
This study investigates the use of umbilical cord mesenchymal stem cells (UC-MSCs) combined with hydroxyapatite (HA) scaffolds for treating vertebral bone defects caused by spondylitis tuberculosis. T...
KEY FINDING: The study found increased bone formation at the defect site over six months, with 75-100% of the bone area showing formation. This suggests the stem cell and scaffold combination supports bone regeneration.
Redox Biology, 2025 • December 12, 2024
This study investigates the role of macropinocytosis in foam cell formation following spinal cord injury (SCI). It demonstrates that foam cells are primarily derived from macrophages and that macropin...
KEY FINDING: Foam cells formed after myelin debris internalization were predominantly macrophages rather than microglia after spinal cord injury.
Journal of Neuroinflammation, 2016 • September 7, 2016
The study explored the antibody signature of SCI patients using SAS, identifying 19 distinct antigenic targets with increased reactivity in SCI patients compared to healthy controls. Reactivity toward...
KEY FINDING: Nineteen antigenic targets with increased reactivity in SCI patients were identified using serological antigen selection (SAS).