Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 481-490 of 620 results
The Journal of Neuroscience, 2011 • March 16, 2011
This study investigates the cellular and molecular changes following peripheral nerve grafts and aFGF treatment that improve hindlimb locomotor function in spinal cord-transected rats. The repair stra...
KEY FINDING: The study found that a combination of peripheral nerve grafts and acidic fibroblast growth factor (aFGF) induced higher levels of interleukin-4 (IL-4), IL-10, and IL-13 in the graft areas of rat spinal cords.
Brain Behav Immun, 2025 • March 1, 2025
This study demonstrates that blocking or deleting the neonatal Fc receptor (FcRn) can alleviate neuropathic pain in mice after sciatic nerve injury. The researchers used efgartigimod, an FcRn blocker,...
KEY FINDING: Efgartigimod, an FcRn blocker, alleviated mechanical allodynia when administered either 7 or 28 days post-CCI.
Nat Med, 2016 • July 1, 2016
This study introduces a novel xenotransplantation model using humanized ossicles to improve the engraftment of human hematopoietic cells, including leukemic cells. The humanized ossicles support robus...
KEY FINDING: Humanized ossicles exhibit robust engraftment of normal human hematopoietic stem and progenitor cells.
Heliyon, 2023 • October 13, 2023
The study demonstrated that intravenously administered RIPCs significantly improved neuropathic pain symptoms, specifically thermal hyperalgesia and mechanical allodynia, in rats with partial sciatic ...
KEY FINDING: Intravenous administration of RIPCs was most effective in reducing thermal hyperalgesia and mechanical allodynia in rats with neuropathic pain.
Neural Regen Res, 2023 • July 1, 2023
This review summarizes the important metabolic pathways involved in SCI as well as the importance of enolase activity on the cell surface following SCI. Interaction at the cell surface allows enolase ...
KEY FINDING: Enolase promotes both pro- and anti-inflammatory events and regulates functional recovery in SCI.
The Journal of Neuroscience, 2017 • November 29, 2017
The study investigates the effect of Maresin 1 (MaR1) on inflammatory resolution and neurological recovery after spinal cord injury (SCI) in mice. It was found that the biosynthesis of specialized pro...
KEY FINDING: SPM biosynthesis is impaired after SCI, with delayed synthesis of SPMs derived from AA, DHA, and EPA.
Bioactive Materials, 2024 • January 1, 2024
This study introduces an innovative approach to treating spinal cord injury (SCI) by transplanting engineered mitochondrial compounds that target macrophages. The engineered Mito-Tpp-CAQK compound enh...
KEY FINDING: Engineered mitochondrial compounds (Mito-Tpp-CAQK) significantly enhanced macrophage phagocytosis of myelin debris both in vitro and in vivo.
mBio, 2021 • April 27, 2021
This study identifies HMGB1 as an architectural factor in Plasmodium falciparum, crucial for maintaining genome organization. HMGB1 is found to be enriched in centromeric regions and its loss leads to...
KEY FINDING: HMGB1 is primarily located in the centromeric regions of Plasmodium falciparum chromosomes.
Neural Regeneration Research, 2014 • October 1, 2014
Spinal cord injury (SCI) is a devastating type of neurological trauma with limited therapeutic opportunities. The pathophysiology of SCI involves primary and secondary mechanisms of injury. Among all ...
KEY FINDING: Inflammation, mediated by activated microglia/macrophages, plays an important role in the clearance of damaged and degenerating tissues following SCI.
The Journal of Neuroscience, 1995 • December 1, 1995
This study demonstrates extensive spontaneous CNS remyelination in β2-microglobulin-deficient mice chronically infected with Theiler's murine encephalomyelitis virus (TMEV). Remyelination was observed...
KEY FINDING: β2m(-/-) mice exhibit extensive spontaneous remyelination in the CNS following Theiler’s virus infection, unlike the minimal remyelination seen in control mice.