Immunology Research

KEY FINDING: The guanidine-hydrochloride-based storage buffer (SSB-4M) is compatible with commercially available and in-house GuHCl-based RNA extraction methods.

KEY FINDING: Macrophages are recruited to both the epicenter and lumbar cord after thoracic SCI, and they persist for at least seven days.

KEY FINDING: RTL401 treatment, administered after the peak of EAE, significantly lowered disease scores and the cumulative disease index (CDI) in mice, indicating a therapeutic effect during the relapsing phase of the disease.

KEY FINDING: There is a significant correlation between semi-quantitative SARS-CoV-2 IgG ratio values and in vitro antibody functionality.

KEY FINDING: White matter injury (WMI) significantly contributes to neurological dysfunction after intracerebral hemorrhage (ICH), often more than previously recognized gray matter injuries.

KEY FINDING: PAR-1 null mice showed reduced neutrophil infiltration and improved vascular integrity after spinal cord injury compared to wild-type mice.

KEY FINDING: Three distinct macrophage subtypes were identified in the injured spinal cord: border-associated macrophages (BAMs), inflammatory macrophages (IMs), and chemotaxis-inducing macrophages (CIMs).

KEY FINDING: DSCM@EVs promote NSC differentiation into neurons and suppress astrocyte formation, alleviating SCI in mice.

KEY FINDING: SCI triggers diverse glial activation and cellular recruitment with complex downstream effects on neuronal function.

KEY FINDING: Artemisinin-resistant malaria is increasing in the Horn of Africa and is coupled with the spread of parasites undetectable by standard rapid diagnostic tests.