Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 591-600 of 620 results
Open Life Sciences, 2024 • October 18, 2024
This study explored the therapeutic potential of major ozonated autohemotherapy (MOA) for spinal cord injury (SCI) in rats. MOA treatment led to improved motor function, reduced bladder dysfunction, a...
KEY FINDING: MOA treatment improved locomotor scores and reduced residual urine volume in rats after SCI, indicating improved motor and bladder function.
iScience, 2023 • January 20, 2023
This study investigates the metabolic mechanisms underlying artemisinin resistance (ART-R) in Plasmodium falciparum, focusing on the role of PfKelch13 mutations and ring-stage growth arrest. The resea...
KEY FINDING: PfKelch13 mutant parasite lines exhibit reduced susceptibility to DHA and prolonged ring stage.
Journal of Orthopaedic Translation, 2025 • January 8, 2025
This study investigates the role of ISRIB in promoting neural functional recovery following SCI and elucidates its underlying molecular mechanisms. The findings revealed that ISRIB suppressed apoptosi...
KEY FINDING: ISRIB suppresses neuron death and neuroinflammation following SCI.
Clinical Pharmacology in Drug Development, 2021 • March 1, 2021
This study reports the first clinical experience with MW189, a novel CNS-penetrant small molecule that selectively suppresses injury- and disease-induced glial proinflammatory cytokine overproduction....
KEY FINDING: MW189 was safe and well tolerated in single and multiple doses up to 0.25 mg/kg, with infusion-site reactions being the most common adverse event.
Neural Regeneration Research, 2024 • January 31, 2024
This study demonstrates that RUX promotes functional recovery after SCI by enhancing motor function and axon regeneration. RUX restores the expression of EAAT2 in astrocytes, reduces inflammation, and...
KEY FINDING: Ruxolitinib promotes motor function recovery and neuronal survival after spinal cord injury in mice.
Journal of Neuroinflammation, 2011 • August 30, 2011
Successful peripheral axon regeneration is associated with a rapid and efficient inflammatory response that is terminated in due course. Schwann cells and macrophages communicate via cytokine networks...
KEY FINDING: Axon degeneration in the distal nerve instigates subsequent degenerative processes after PNI; however, axon degeneration does not begin immediately.
Nat Protoc, 2017 • October 1, 2017
The study presents a detailed protocol for generating humanized bone marrow ossicles in mice to improve the study of human hematopoiesis and leukemia. This method involves in situ differentiation of b...
KEY FINDING: The ossicles allow for accelerated and superior engraftment of primary patient-derived acute myeloid leukemia (AML) and other hematologic malignancies such as myelofibrosis (MF) in mice.
Antibiotics, 2022 • December 13, 2022
This retrospective study evaluated urine cultures from a rural hospital in Ghana between October 2019 and December 2021 to assess antimicrobial resistance (AMR) rates of uropathogens. The study found ...
KEY FINDING: Escherichia coli was the most frequently identified bacterial species in positive urine cultures, representing 42.7% of cases.
JOURNAL OF VIROLOGY, 1999 • July 1, 1999
This study demonstrates that poliovirus (PV) infection in mice leads to apoptosis in the central nervous system (CNS), contributing to the paralysis observed in poliomyelitis. Both neurovirulent and a...
KEY FINDING: PV infection causes cleavage of DNA into nucleosomes in the mouse CNS, indicating apoptosis.
Top Spinal Cord Inj Rehabil, 2017 • July 1, 2017
The inflammatory response plays a significant role in both the acute and chronic phases of SCI as an interrelated, multifactorial process that adversely impacts health and quality of life after injury...
KEY FINDING: Chronic inflammation worsens secondary medical complications and amplifies the risk for cardiometabolic disorders after injury, directly impacting both the quality of life and mortality risk after SCI.