Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,101-5,110 of 5,253 results
Int. J. Mol. Sci., 2023 • December 4, 2023
The mammalian central nervous system (CNS) is built up during embryogenesis by neural stem cells located in the periventricular germinal layers which undergo multiple division cycles. Hence, the matur...
KEY FINDING: Slowing down neuronal maturation to extend the period of immaturity might have been a useful strategy for accommodating the brain with “young” cells and neotenic features over longer windows of time, even in the absence of active neural stem cells.
The Journal of Neuroscience, 1991 • February 1, 1991
This study investigates the distribution of FGFs in the rat nervous system by measuring the effect of heparin on the mitogenic activity in extracts prepared from different areas of the rat nervous sys...
KEY FINDING: Sciatic nerve contained extremely high levels of only aFGF, while spinal cord, cortex, pituitary, and optic nerve contained different ratios of aFGF to bFGF.
N Biotechnol, 2013 • June 25, 2013
Optogenetics, particularly using channelrhodopsins, offers precise control over cellular activity via light, with potential therapeutic applications for neurological and retinal disorders. Channelrhod...
KEY FINDING: Optogenetic tools, particularly channelrhodopsins, can be used to control neural circuits and restore function in various tissues.
Int. J. Mol. Sci., 2023 • June 30, 2023
This study investigates the transcription patterns of neurotrophins and their receptors in the adult zebrafish spinal cord, using qPCR and in situ hybridization techniques. The results indicate that n...
KEY FINDING: Ngf mRNA is highly expressed in the spinal cord compared with the brain, and it is the most expressed transcript in the whole adult zebrafish spinal cord, compared to other neurotrophic factors.
Neural Regen Res, 2018 • August 1, 2018
The perspective piece emphasizes the complex and dynamic nature of the glial scar following spinal cord injury (SCI), moving beyond the outdated view of it being a simple barrier composed only of astr...
KEY FINDING: The glial scar is a multicellular structure comprising astrocytes, oligodendrocyte progenitor cells, microglia, macrophages, and fibroblasts/pericytes, all responding to the inflammatory environment after SCI.
Neural Regeneration Research, 2016 • February 1, 2016
The study used the SmartCage system to monitor early neurobehavioral changes in mice following traumatic brain injury (TBI). It focused on detecting changes in locomotor activity, sleep patterns, and ...
KEY FINDING: Spontaneous activities, including travelled distance and rearing up counts, were significantly decreased in mice receiving CCI at 1 and 2 days after injury, which was strongly correlated with neurological score and tissue damage.
Exp Neurol, 2011 • October 1, 2011
This study demonstrates that acute MMP-9/2 inhibition after spinal cord dorsal hemisection acts as a mitogen for NG2+ cells but not GFAP+ astrocytes or Iba-1+ macrophages and/or microglia. In the dama...
KEY FINDING: Acute inhibition of MMP-9/2 after spinal cord injury increases the proliferation of NG2+ progenitor cells but not astrocytes or microglia.
Neural Regeneration Research, 2016 • May 1, 2016
This study investigates the effects of repetitive magnetic stimulation (rMS) on nerve regeneration after spinal cord injury (SCI) in rats. The study found that rMS improved the microenvironment of neu...
KEY FINDING: Repetitive magnetic stimulation reduced the number of apoptotic cells in the injured spinal cord.
Journal of Orthopaedic Translation, 2025 • January 8, 2025
This study investigates the role of ISRIB in promoting neural functional recovery following SCI and elucidates its underlying molecular mechanisms. The findings revealed that ISRIB suppressed apoptosi...
KEY FINDING: ISRIB suppresses neuron death and neuroinflammation following SCI.
Scientific Reports, 2019 • June 13, 2019
The study aimed to validate a fetal lamb model for spina bifida (SB) research, comparing two surgical models (with and without myelotomy) to normal lambs. The myelotomy model best phenocopied the anat...
KEY FINDING: The myelotomy model best replicates the anatomy, pathophysiology, and symptoms of non-cystic spina bifida (SB).