Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 111-120 of 555 results
BMJ Case Reports, 2021 • September 15, 2021
Intrathecal baclofen is recognised as an effective treatment option for severe symptoms of segmental spasticity after spinal cord injury. We suggest an effective bridging and weaning protocol for oral...
KEY FINDING: Sudden removal of an intrathecal baclofen pump can lead to severe withdrawal symptoms, including increased spasticity, pain, and seizures.
Frontiers in Pharmacology, 2021 • September 13, 2021
This study investigates the effects of long-term nimodipine (NMD) administration on functional recovery in rats with spinal cord injury (SCI). The results indicate that NMD improves locomotor function...
KEY FINDING: Long-term NMD administration improves locomotor function in rats with SCI without affecting hind limb grip strength.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
This pilot study assessed the feasibility and potential benefits of a Clinical Meditation and Imagery (CMI) intervention for people with chronic pain after spinal cord injury (SCI). The study found th...
KEY FINDING: Pain interference decreased more in the control group, contrary to the initial hypothesis.
Neural Plasticity, 2021 • October 21, 2021
The analgesic mechanisms of SCS are gradually unveiled with the involvement of the “Gate control” theory, segmental inhibition, the descending inhibitory system, and cortical modulation. It is recomme...
KEY FINDING: SCS modulates nociceptive processing by inhibiting ascending nociceptive transmission via GABA and endocannabinoids, facilitating descending inhibition by releasing noradrenalin, dopamine, and serotonin, and activating supraspinal brain areas related to pain perception and emotion.
JRM-CC, 2021 • August 26, 2021
SAC are rare lesions that may present with a constellation of neurological symptoms: paraesthesia, neuropathic pain, paresis and gait disturbances, just like a (progressive) spinal cord injury due to ...
KEY FINDING: Spinal arachnoid cysts may present with a heterogeneous clinical picture.
Neurotrauma Reports, 2021 • January 1, 2021
This study investigated the role of microRNAs (miRNAs) in neuropathic pain following spinal cord injury (SCI) by screening miRNA expression in plasma samples from individuals with and without SCI. The...
KEY FINDING: 383 miRNAs were differentially expressed in acute or chronic SCI versus no SCI.
Frontiers in Pain Research, 2022 • July 28, 2022
This review explores the emerging evidence for intrathecal management of neuropathic pain following spinal cord injury (SCI). It highlights the challenges in treating neuropathic pain in SCI patients ...
KEY FINDING: Neuropathic pain after SCI involves complex mechanisms including neuronal excitability, glial dysregulation, and chronic inflammation.
AGING, 2021 • November 12, 2021
This study investigates the role of RIP3-induced JNK signaling in chronic constriction injury (CCI)-induced neuropathic pain. The findings demonstrate that RIP3 inhibition alleviates neuropathic pain ...
KEY FINDING: RIP3 inhibitors (GSK’872) and JNK inhibitors (SP600125) alleviated pain and reduced inflammatory factor levels in CCI rats.
Brain Sci., 2021 • October 28, 2021
This study investigated the effects of whole-body extremely low-frequency electromagnetic field (EMF) stimulation on nociception and sensorimotor deficits in rats with complete thoracic spinal cord in...
KEY FINDING: EMF stimulation significantly attenuated hyperalgesia and allodynia to thermal, electrical, and chemical stimuli from 6 weeks onwards in rats with complete SCI.
Frontiers in Medicine, 2021 • November 24, 2021
This systematic review and expert consensus evaluated the effectiveness and efficacy of exercise for neuropathic pain (NP) across various diseases. The study aimed to provide evidence-based exercise r...
KEY FINDING: Exercise is helpful to alleviate NP intensity, recommending it as an effective alternative or complementary therapy.