Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 221-230 of 555 results
Spinal Cord Series and Cases, 2022 • November 29, 2022
This study reviewed the use of phenol neurolysis for spasticity management in 66 people with spinal cord injury (SCI). The study found that phenol neurolysis, guided by electrical stimulation and ultr...
KEY FINDING: The obturator nerve (33%) and pectoral nerves (23%) were the most frequent targets for phenol neurolysis in people with SCI.
Neurosci. Bull., 2020 • September 5, 2020
The study examined the effects of conventional spinal cord stimulation (SCS) on microglial activation in rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain. ...
KEY FINDING: Conventional SCS transiently attenuated mechanical hypersensitivity in rats with chronic constriction injury (CCI) of the sciatic nerve.
Molecular Pain, 2021 • January 1, 2021
In healthy adult rodents, descending serotonergic modulation inhibits nociceptive transmission via 5-HT1a, 5-HT1b, 5-HT2c, 5-HT3, and 5-HT4 receptors. In chronic pain, this balance shifts towards faci...
KEY FINDING: In healthy rodents, serotonin generally inhibits pain signals in the spinal cord via receptors like 5-HT1a, 5-HT1b, 5-HT2c, 5-HT3, and 5-HT4.
Neural Plasticity, 2021 • April 19, 2021
The study investigates the role of the Wnt/β-catenin pathway in neuropathic pain (NP) induced by chronic compression of the dorsal root ganglion (DRG). The researchers used a rat model to mimic lumbar...
KEY FINDING: Chronic compression of the DRG leads to changes in the expression of multiple Wnt pathway-related genes and rapid activation of the Wnt/β-catenin pathway in the DRG and spinal cord.
Journal of International Medical Research, 2019 • April 1, 2019
The study aimed to determine the role of spinal adenosine A1 receptors (A1Rs) in the analgesic effects of electroacupuncture (EA) for neuropathic pain using a rat model. Results showed that EA increas...
KEY FINDING: Electroacupuncture (EA) at the zusanli acupoint increases adenosine levels in the L4–6 spinal cord of rats.
The Journal of Spinal Cord Medicine, 2020 • May 1, 2020
This scoping review analyzed the extent, range and nature of available research on what is known about the self-management of pain and depression through the use of pharmacological and non-pharmacolog...
KEY FINDING: The majority of studies have focused on self-management of pain, with fewer focusing on depression or both.
Nutrients, 2020 • January 3, 2020
The study investigates the antinociceptive and anti-inflammatory effects of Nypa fruticans Wurmb extracts (NFE) in a rat model of sciatic nerve crush injury, focusing on the role of TRPV1. Results ind...
KEY FINDING: NFE (500 mg/kg) significantly delayed paw withdraw reaction in thermal hyperalgesia test compared to the vehicle group.
Nature Communications, 2019 • September 13, 2019
This study identifies circAnks1a as a key regulator in neuropathic pain, showing its expression is increased following nerve injury in a rodent model. Reducing circAnks1a levels alleviates pain-like b...
KEY FINDING: Spinal nerve ligation increases circAnks1a expression in dorsal horn neurons.
Journal of Orthopaedic Surgery and Research, 2021 • May 5, 2021
This study analyzed the effects of different analgesics on pain and functional recovery in patients with thoracolumbar fractures. Patients were divided into acetaminophen dihydrocodeine, celecoxib, an...
KEY FINDING: Severe spinal cord injury and peri-treatment use of acetaminophen dihydrocodeine were risk factors for postoperative chronic pain.
Neuromodulation, 2021 • April 1, 2021
The study explored the effects of central neuromodulation on autonomic function and pain in SCI+NP and AB cohorts. Active BreEStim led to analgesia and increased parasympathetic tone in SCI+NP individ...
KEY FINDING: SCI+NP persons demonstrated increased parasympathetic tone (increased NN50, p=0.03, and pNN50, p=0.02, HRV parameters) following active BreEStim only.