Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 231-240 of 555 results
Evidence-Based Complementary and Alternative Medicine, 2022 • October 7, 2022
This study investigates the analgesic effects of electroacupuncture (EA) on neuropathic pain in a chronic constriction injury (CCI) rat model. The research focuses on the role of GABAA receptors and m...
KEY FINDING: EA treatment relieves mechanical allodynia and thermal hyperalgesia in CCI rats, as demonstrated by increased MWT and TWL values compared to the CCI group.
Pain Practice, 2020 • January 1, 2020
This study investigates the role of GABAergic mechanisms in the analgesic effects of burst and tonic spinal cord stimulation (SCS) in a rat model of chronic neuropathic pain induced by partial sciatic...
KEY FINDING: Burst SCS significantly lowers intracellular GABA levels in the spinal dorsal horn compared to sham SCS and tonic SCS.
Neural Plasticity, 2021 • April 13, 2021
This study investigates the effect of LIFU on neuropathic pain (NP) and the expression of potassium chloride cotransporter 2 (KCC2) in the spinal cords of rats with peripheral nerve injury (PNI). The ...
KEY FINDING: LIFU stimulation alleviated mechanical allodynia in PNI model rats, as indicated by increased PWT50 values after 3 weeks of LIFU treatment compared to the LIFU− group.
International Journal of Molecular Sciences, 2020 • September 7, 2020
This study investigates the mechanisms by which 2 Hz electroacupuncture (EA) alleviates neuropathic pain in spared nerve injury (SNI) rats, focusing on the spinal BDNF/TrκB signaling pathway. The resu...
KEY FINDING: 2 Hz EA significantly down-regulated the levels of BDNF and TrκB mRNA and protein expression in the spinal cord of SNI rats, along with ameliorating mechanical hypersensitivity.
Frontiers in Human Neuroscience, 2020 • January 10, 2020
The study investigated contact heat stimulation parameters to detect peripheral sensitization related to topical capsaicin application, aiming to improve CHEP-based measurement of sensitization. Resul...
KEY FINDING: Capsaicin sensitization resulted in increased pain ratings in the primary area of hyperalgesia.
Chinese Medical Journal, 2020 • January 1, 2020
This study investigated the effect of pulsed radiofrequency (PRF) on neuropathic pain (NP) in a rat model of chronic constriction injury (CCI). The findings suggest that PRF alleviates CCI-induced NP ...
KEY FINDING: PRF treatment significantly increased hindpaw withdrawal threshold (HWT) and thermal withdrawal latency (TWL) in CCI model rats after 28 days.
International Journal of Molecular Sciences, 2020 • January 31, 2020
The study demonstrates that Syt-1 plays a role in the development of neuropathic pain. Electroacupuncture can alleviate neuropathic pain, possibly by suppressing Syt-1 protein expression in the spinal...
KEY FINDING: Syt-1 antibody blockade and siRNA silencing increased pain thresholds in SNI rats.
Journal of Clinical Medicine, 2020 • January 5, 2020
This study assessed the perceived helpfulness of various treatment modalities within a multidisciplinary pain management program (MPMP) for chronic back pain (CBP) patients. The study found that patie...
KEY FINDING: Patients' perceived treatment helpfulness differs significantly between treatment modalities, with individual physiotherapy being rated the highest and music therapy the lowest.
Cells, 2022 • September 30, 2022
This review examines the potential of activity-based interventions (ABI) to alleviate neuropathic pain (NP) following spinal cord injury (SCI) in preclinical rodent models. It focuses on molecular and...
KEY FINDING: Weight-bearing rhythmic activity-based paradigms seem effective for neuropathic pain relief after spinal cord injury, regardless of whether interventions are started early or delayed, or applied for short or long durations, but the benefits may not persist long after halting the interventions.
Molecular Pain, 2021 • February 4, 2021
This study investigates the potential of electroacupuncture (EA) to alleviate neuropathic pain by suppressing P2X7R expression in a rat model of spinal nerve ligation (SNL). The research aims to under...
KEY FINDING: EA treatment increased pain threshold in SNL rats, indicating pain relief, while the P2X7R agonist BzATP suppressed this EA-induced increase.