Pain Management Research

KEY FINDING: The study confirmed a higher occurrence of CRPS in females. The hand and wrist were the most commonly affected areas, followed by the ankle and foot.

KEY FINDING: There were no adverse events in physical condition, laboratory data, or lumbar X-rays after injection, suggesting that PRP intradiscal injection is safe.

KEY FINDING: HBOT and TAK-242 alleviated behavioral signs of CIPN, specifically mechanical allodynia and thermal hyperalgesia, in rats treated with paclitaxel and LPS.

KEY FINDING: The Gel-Cur-M exhibited superior functions compared to Gel and Cur-M alone, which includes ameliorating hyperalgesia while simultaneously improving locomotor and muscular functions after the nerve injury.

KEY FINDING: High-intensity swimming (HIS), but not low-intensity swimming (LIS), significantly alleviated mechanical and thermal hyperalgesia in CPIP mice.

KEY FINDING: Mind body therapy, biopsychosocial approach, and physical therapy were effective in reducing depression compared to the control group.

KEY FINDING: Peripheral HCN2 ion channels drive opioid-induced hyperalgesia (OIH). Blocking or genetically deleting HCN2 in primary nociceptive neurons abolishes OIH.

KEY FINDING: PLDD significantly reduced the patient's discomfort within 24 hours.

KEY FINDING: TMS significantly improved SCI induced mechanical allodynia, cold and thermal hyperalgesia with a durative effect, and TMS intervention at 1 week after SCI had pain relief advantages than at 2 weeks.

KEY FINDING: LGI1 is highly expressed in dorsal root ganglion (DRG) and spinal cord dorsal horn neurons in both mouse and human.