Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 531-540 of 555 results
Korean J Neurotrauma, 2025 • January 23, 2025
This case report describes a 36-year-old woman who developed left-sided hemiparesis following IDET for cervical disc herniation. MRI revealed cervical cord edema, and examination showed neurological d...
KEY FINDING: The patient experienced left-sided hemiparesis after IDET, indicating neurological damage. MRI confirmed cervical cord edema.
Brain Res, 2007 • September 7, 2007
This study demonstrates that paclitaxel induces injury of sensory neurons, morphological and biochemical alterations in DRG satellite cells, hyperplasia/hypertrophy of macrophages in the peripheral ne...
KEY FINDING: ATF3, a marker of cell injury, is upregulated in DRG neurons as early as day 1 after paclitaxel infusion. This indicates early neuronal stress or damage.
J Comp Neurol, 2016 • February 1, 2016
We examined whether there were changes in the number of different types of synapses during the development of chronic orofacial pain after CCI-ION. Our data indicate that trigeminal nerve injury leads...
KEY FINDING: Trigeminal nerve injury leads to an increase in R-synaptic profiles (presumably excitatory synapses) in lamina I of Vc/C2.
Behavioral and Brain Functions, 2013 • June 7, 2013
The study evaluated the impact of environmental enrichment or impoverishment in mice three months after induction of chronic neuropathic pain. Environmental enrichment attenuated nerve injury-induced ...
KEY FINDING: Environmental enrichment attenuated nerve injury-induced hypersensitivity to mechanical and cold stimuli.
Journal of Orthopaedic Surgery and Research, 2017 • March 24, 2017
This study investigates the roles of iron overload and subsequent microglia activation in the remodeling of the brain after SCI. The results indicate that after SCI, activation of IRP can lead to intr...
KEY FINDING: SCI induces intracranial iron overload, especially in the hindlimb sensory area, hippocampus, and thalamus.
Neural Regeneration Research, 2017 • March 1, 2017
The study aimed to determine whether a relationship exists between estrogen and NMDAR1 in peripheral nerve pain using a rat model of chronic sciatic nerve constriction injury. Rats administered estrad...
KEY FINDING: Estrogen administration significantly reduced mechanical and thermal pain thresholds in rats with chronic constriction of the sciatic nerve.
Scientific Reports, 2016 • December 20, 2016
This study investigates the crosstalk between activated microglia and neurons in the spinal dorsal horn and its contribution to stress-induced hyperalgesia using a rat model combining single-prolonged...
KEY FINDING: The study found that stress combined with inflammation (using Complete Freund’s Adjuvant) significantly increased pain sensitivity (mechanical allodynia) in rats.
Molecular Pain, 2011 • January 5, 2011
This study investigates whether a preconditioning nerve lesion influences pain sensation and neuroinflammation following a subsequent peripheral nerve injury. The results show that a preconditioning c...
KEY FINDING: A preconditioning crush injury to the tibial nerve significantly attenuated mechanical allodynia and thermal hyperalgesia following partial sciatic nerve ligation (PSNL).
Journal of Inflammation Research, 2025 • February 17, 2025
This study investigated the synergistic effects of combining Shinbaro and celecoxib in a mouse model of CFA-induced inflammatory pain. The results demonstrated that the combination therapy effectively...
KEY FINDING: The combination of Shinbaro and celecoxib synergistically reduced mechanical hyperalgesia and paw edema in mice with CFA-induced inflammatory pain.
Medicine, 2017 • October 20, 2017
This case report describes a patient with cervical spinal cord injury who presented with neck-to-shoulder pain, which was later diagnosed as pulmonary embolism. The patient's pain was initially though...
KEY FINDING: Neck-to-shoulder pain can be an atypical symptom of pulmonary embolism, especially in patients with cervical spinal cord injury.