Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 541-550 of 555 results
Curr Pain Headache Rep, 2013 • January 1, 2013
Psychological screening and QST can help predict SCS outcomes. Psychological factors such as depression and anxiety are key predictors of success. QST measures, including pain thresholds and temporal ...
KEY FINDING: Psychological factors like somatization, depression, and anxiety are strong predictors of poor response to spinal cord stimulation.
Molecular Medicine Reports, 2018 • May 8, 2018
The study demonstrated that EA treatment has a beneficial effect on the pain threshold of rats undergoing CCI, increasing mechanical and thermal nociceptive thresholds. EA treatment significantly incr...
KEY FINDING: EA treatment significantly improved mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) in CCI model rats, indicating reduced pain.
Neural Regen Res, 2018 • June 1, 2018
This study investigates the analgesic effect of AG490 on oxaliplatin-induced acute neuropathic pain in rats. The findings demonstrate that AG490 attenuates oxaliplatin-induced acute neuropathic pain b...
KEY FINDING: AG490 treatment significantly increased paw withdrawal threshold and tail withdrawal latency in rats with oxaliplatin-induced neuropathic pain, indicating reduced sensitivity to mechanical and cold stimuli.
Molecular Pain, 2024 • April 1, 2024
The study analyzed alternative splicing (AS) patterns in mouse brain, dorsal root ganglion (DRG), and spinal cord tissues under inflammatory and neuropathic pain conditions to understand the molecular ...
KEY FINDING: The study identified 6495 differentially alternatively spliced (DAS) genes in the mouse brain, dorsal root ganglion, and spinal cord tissue under inflammatory and neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018 • January 23, 2018
The study demonstrates that electro-acupuncture (EA) can alleviate neuropathic pain in a rat model of chronic constrictive injury (CCI). EA treatment reduces mechanical allodynia and thermal hyperalge...
KEY FINDING: EA treatment significantly increased mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) values, indicating reduced hyperalgesia and allodynia in CCI rats.
Spinal Cord Series and Cases, 2019 • June 26, 2019
This study explored the utilization of medicinal cannabis (MC) among individuals with spinal cord injury (SCI) to manage pain and other symptoms. The research compared current, past, and never users o...
KEY FINDING: Current and past MC users reported greater pain interference in daily life compared to never users.
Gene, 2011 • July 1, 2011
The study demonstrates that miR-146a regulates cartilage-degrading proteases and pain-associated inflammatory molecules in knee joint tissues. MiR-146a functions in an anti-catabolic manner by antagon...
KEY FINDING: MiR-146a suppresses extracellular matrix proteins in human knee chondrocytes and regulates inflammatory cytokines in human knee joint synovial cells.
Cureus, 2023 • July 31, 2023
Diagnosis of low back pain combines old and new methodologies, in particular, it involves an expanded role for ultrasound. Tumors and infections are rarely involved in low back pain but should be rule...
KEY FINDING: Autologous blood products like platelet-rich plasma are safe and effective in stimulating the body’s regenerative responses for musculoskeletal pain.
J Spinal Cord Med, 2005 • July 1, 2005
This paper presents two cases of individuals with spinal cord injury (SCI) who experienced late complications from thoracolumbar fusion instrumentation, specifically displaced hooks and protruding rod...
KEY FINDING: Both individuals experienced back pain from proximal hook displacement, without neurologic decline.
J Pain, 2007 • September 1, 2007
This study investigated the influence of psychosocial variables on adjustment to chronic pain in individuals with spinal cord injury (SCI). It examined the relationships between pain-related beliefs, ...
KEY FINDING: Greater catastrophizing and the belief that pain signals damage were linked to increased pain interference and poorer mental health.