Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 131-140 of 2,317 results
Stem Cell Research & Therapy, 2021 • January 7, 2021
This review discusses the potential of mesenchymal stem cell (MSC)-derived exosomes as a therapeutic strategy for spinal cord injury (SCI), highlighting their advantages over traditional MSC therapy. ...
KEY FINDING: Exosomes derived from MSCs have anti-inflammatory effects, reducing pro-inflammatory cytokines and promoting an anti-inflammatory environment conducive to functional recovery after SCI.
Cell Transplantation, 2021 • January 4, 2021
Stem cells have neuroregenerative and neuroprotective effects in SCI cell therapy. Cell-based therapies in SCI have different mechanisms in functional recovery, such as immunomodulation, cell replacem...
KEY FINDING: BM-MSC therapy is beneficial for SCI recovery by improving the microenvironment of the injury site, enhancing nutritional support, modulating the inflammatory response, and alleviating BSCB leakage.
Exp Neurol, 2021 • May 1, 2021
The study confirms that KLF6 can enhance axon sprouting in the corticospinal tract but only when there's an injury. This sprouting occurs noticeably within four weeks of KLF6 treatment. Despite the in...
KEY FINDING: KLF6's pro-growth effects on corticospinal tract axons require an injury stimulus, as KLF6 expression alone did not trigger sprouting.
Cell Biosci, 2021 • January 1, 2021
A series of pathophysiological changes occur after SCI. The primary injury is related to the destruction of axons and neurons. The secondary injury is caused by nerve inflammation, which directly or i...
KEY FINDING: MSCs can regulate macrophage polarization by secreting soluble proteins, including ILs and chemokines, which ultimately relieve SCI.
MOLECULAR MEDICINE REPORTS, 2021 • January 7, 2021
The study aimed to compare the therapeutic effects of monotherapy (TMS, BMSCs, or RafI) and combination therapy (TMS+BMSCs or TMS+RafI) on spinal cord injury (SCI) in rats. The results demonstrated th...
KEY FINDING: Monotherapy (TMS, BMSCs, or RafI) significantly enhanced locomotor functional recovery in SCI model rats, as evidenced by higher BBB scores, and slightly alleviated histopathological lesions of the spinal cord.
AGING, 2021 • March 4, 2021
The SCI microenvironment leads to necroptosis of grafted NSCs via RIP3/MLKL, inhibiting their survival and therapeutic efficacy. Transplanted OECs counteract SCI-induced necroptosis, protecting co-tra...
KEY FINDING: OEC/NSC co-transplantation improved motor function and autonomic nerve function in rats with SCI.
Stem Cell Research & Therapy, 2021 • January 31, 2021
This study demonstrates that NCSCs delivered at the injury site using a scaffold ameliorate neuropathic pain and enhance locomotion after PNI through inhibiting glial activation as well as ERK and NF-...
KEY FINDING: NCSC-laden nerve scaffolds mitigated SNT-induced neuropathic pain and improved motor function recovery after sciatic nerve repair.
J Transl Med, 2021 • May 7, 2021
This meta-analysis evaluated the efficacy and safety of MSCs in treating SCI, exploring optimal cell sources and transplantation methods. The study found that MSCs transplantation significantly improv...
KEY FINDING: MSCs significantly improved ASIA motor score, sensory score, ASIA grade, and BI compared to rehabilitation.
eLife, 2021 • May 4, 2021
The study investigates dorsal root (DR) regeneration after injury, focusing on the roles of myelin inhibitors and chondroitin sulfate proteoglycans (CSPGs). It finds that co-eliminating myelin inhibit...
KEY FINDING: Genetic deletion of myelin inhibitors (Nogo, MAG, OMgp) alone elicits little regeneration across the dorsal root entry zone (DREZ).
Cells, 2021 • May 12, 2021
This study demonstrates that increasing the yield of olfactory ensheathing cells (OECs) from mucosal cultures can promote axonal regeneration and functional recovery in a rat dorsal root injury model....
KEY FINDING: A modified culture protocol increased the yield of mucosal OECs to approximately 20%, a fourfold increase compared to previous methods.