Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 141-150 of 2,317 results
Open Veterinary Journal, 2021 • June 4, 2021
This study evaluates the use of autologous bone marrow-derived stromal cells in platelet-rich plasma for treating chronic spinal cord injuries in dogs and cats via a one-time combined intrathecal/intr...
KEY FINDING: The combined intrathecal/intravenous injection of bone marrow stromal cells is a safe and promising procedure for treating chronic spinal cord injuries in companion animals.
Biomedicines, 2022 • October 13, 2022
The article reviews current interventions for spinal cord injury (SCI) treatment, focusing on rehabilitation phases and emphasizing a neuroplasticity-based multimodal approach. It highlights the integ...
KEY FINDING: Biomolecular approaches alone have modest outcomes in SCI treatment.
North American Spine Society Journal, 2023 • January 1, 2023
Here we reviewed the overview of regenerative medicine of SCI. At the same time, the search for effective treatments for chronic SCI is proceeding gradually, combining hiPSC-NS/PC transplantation with ...
KEY FINDING: hiPSC-NS/PC transplantation into subacute injured spinal cords has been repeatedly demonstrated to improve locomotor function.
Biomedicines, 2022 • December 6, 2022
Spinal cord injury (SCI) presents a significant unmet clinical need. Olfactory ensheathing cell (OEC) transplantation is a promising therapeutic approach for SCI repair, but variability in clinical ou...
KEY FINDING: OEC transplantation shows promise for SCI repair due to their unique properties in supporting nerve regeneration and modulating the inflammatory response.
Cells, 2023 • December 28, 2022
This review explores the molecular mechanisms of action of multipotent stem cells (MSCs, NSCs, and HSCs) and their clinical efficacy in treating SCI. It discusses the pathogenesis of SCI, optimal stem...
KEY FINDING: MSCs reach the lesion site through the chemotactic mechanism known as a homing effect, which is important for therapy effectiveness.
Int. J. Mol. Sci., 2023 • January 3, 2023
Spinal cord injury (SCI) leads to reduced motor, sensory, and autonomic functions, with an increasing incidence worldwide. Regenerative biomaterials offer a promising treatment option by using tissue ...
KEY FINDING: Hyaluronic acid (HA) reduces glial scar formation and improves the therapeutic effect of SCI by transporting drugs and stem cells to the injury area, enhancing the survival and differentiation of neural stem cells.
Stem Cell Reports, 2023 • January 19, 2023
This study investigates the feasibility of using human pluripotent stem cell (hPSC)-derived spinal GABA neurons to treat spinal cord injury (SCI) in a nonhuman primate (NHP) model. The researchers est...
KEY FINDING: Human spinal GABA neurons, derived from pluripotent stem cells, can survive for up to 7.5 months after transplantation into the injured spinal cord of rhesus macaques.
Frontiers in Pharmacology, 2023 • January 10, 2023
This study investigates the therapeutic potential of iPSCs-Exo in treating spinal cord injury (SCI) in mice, focusing on the role of miR-199b-5p in modulating macrophage polarization and promoting neu...
KEY FINDING: iPSCs-Exo improves motor function in SCI mice and reduces the cavity volume in the injured spinal cord.
Brain Communications, 2023 • January 13, 2023
This study investigates the efficacy of epothilones (epoB and epoD) alone or in combination with rehabilitation for improving functional recovery after a moderate spinal cord injury (SCI) in rats. The...
KEY FINDING: Epothilone B (epoB) reduces fibrotic scarring, which can hinder axon regeneration, after a moderate spinal cord injury.
Cells, 2023 • February 14, 2023
This review analyzes experimental attempts to transform astrocytes into neurons (AtN) in adult animals, a strategy for CNS repair. The paper distinguishes between direct cell conversion and direct cel...
KEY FINDING: Direct cell conversion (1-2 TFs) and direct cell reprogramming (≥3 TFs or multifactor formulas) are proposed as distinct approaches to AtN, influencing the extent of epigenetic modification.