Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 2,211-2,220 of 2,317 results
Nature Communications, 2018 • August 9, 2018
This work is based on the development of a biodegradable hybrid inorganic nanoscaffold and its utilization for the enhanced transplantation of stem cells into SCI sites. Our demonstrated nanoscaffold ...
KEY FINDING: The 3D-MnO2 nanoscaffolds can improve neuronal differentiation and neurite outgrowth, through the enhanced laminin binding and focal adhesion-related pathways.
Data in Brief, 2018 • November 4, 2017
The study investigates spinal cord regeneration in larval zebrafish after mechanical transection, focusing on the restoration of anatomical continuity. Spreading of fluorescently-labelled dextran alon...
KEY FINDING: Anatomical continuity is rapidly restored after complete spinal cord transection in larval zebrafish.
PLoS ONE, 2014 • July 22, 2014
This study investigated cell proliferation and neurogenesis in remote CNS areas following a contusion injury in rats to understand spontaneous locomotor recovery. The study found no evidence of neurog...
KEY FINDING: Thoracic spinal cord contusion injury induces complete paresis of both hindlimbs in rats.
International Journal of Nanomedicine, 2020 • January 27, 2020
The study explores the impact of graphene oxide nanoparticle (GO NP) size on mouse neural stem cell (mNSC) fate, including self-renewal and differentiation. Results showed that GO NPs generally exhibi...
KEY FINDING: GO NPs of all sizes showed low cytotoxicity at a concentration of 20 μg/mL on the mNSCs.
Neural Regeneration Research, 2023 • May 1, 2023
Spinal cord injury results in the loss of functional mobility, sensations, and neuromuscular and skeletal function. Injury can lead to apoptosis of the neurons and degradation of oligodendrocytes caus...
KEY FINDING: Clemastine enhances oligodendrocyte differentiation and myelination, which helps to delay axonal degeneration and promote motor function recovery in rat SCI models.
Front. Mol. Neurosci., 2018 • May 24, 2018
This study investigated the role of CHL1 in peripheral nerve regeneration using a mouse model of femoral nerve injury. CHL1-deficient mice were compared to wild-type mice regarding motor function, axo...
KEY FINDING: CHL1-deficient mice showed decreased preferential motor re-innervation, indicating reduced precision in motor axon targeting after nerve injury.
Neural Regen Res, 2025 • May 1, 2025
Spinal cord regeneration is a complex physiological process, and no optimal treatment has yet been developed for fully repairing the spinal cord. Theoretically, combinatorial strategies have the highe...
KEY FINDING: The synergistic effect between anti-Nogo-A antibody and chondroitinase ABC (ChABC) enzyme resulted in superior outcomes, leading to enhanced sprouting and axon regeneration.
Proc. Nati. Acad. Sci. USA, 1986 • April 1, 1986
The study demonstrates that axons in larval sea lampreys can regenerate across a spinal cord transection and form functional synapses. Fictive swimming induced in isolated spinal cords showed phase-lo...
KEY FINDING: Axons in the larval sea lamprey can regenerate across the site of a spinal cord transection and form functioning synapses with some of their normal target neurons.
Heliyon, 2022 • October 13, 2022
This study investigates the dynamics of cartilage-derived stem/progenitor cells (CSPCs) in osteoarthritis (OA) progression using single-cell transcriptomic data. The research reveals that CSPC heterog...
KEY FINDING: CSPCs exhibit significant heterogeneity that is closely associated with the progression of OA, indicating that the characteristics of CSPCs change during OA progression.
NEURAL REGENERATION RESEARCH, 2025 • June 3, 2024
This study investigates the efficacy of combining Schwann cell (SC) transplantation with chondroitinase ABC (ChABC) to enhance neural repair and functional recovery following spinal cord injury (SCI) ...
KEY FINDING: Chondroitinase ABC (ChABC) treatment effectively degraded CSPGs, reduced glial response, and promoted the migration of grafted Schwann cells (SCs) in the injured spinal cord.