Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 2,221-2,230 of 2,317 results
AGING, 2021 • October 14, 2021
This study investigates the potential of resveratrol to improve function recovery after spinal cord injury (SCI) in rats. The researchers found that resveratrol promotes axonal regeneration, improves ...
KEY FINDING: Resveratrol significantly improved the function recovery, promoted axonal regeneration, suppressed apoptosis after SCI in rats.
PLoS ONE, 2014 • January 20, 2014
This study utilizes a high-density microarray to profile the temporal transcriptome dynamics during spinal cord regeneration in zebrafish, identifying 3842 differentially expressed genes. Cluster anal...
KEY FINDING: A total of 3842 genes were found to be differentially expressed during spinal cord regeneration, with maximum numbers of genes differentially expressed at 7 days post injury.
Cell Bioscience, 2021 • March 24, 2021
This study investigates the evolutionary divergence in tail regeneration between Xenopus laevis and Xenopus tropicalis. The researchers found that Xenopus tropicalis lacks the refractory period observ...
KEY FINDING: Xenopus laevis tadpoles exhibit a refractory period (stages 45-47) during which they cannot regenerate their tails after amputation.
Cellular & Molecular Biology Letters, 2022 • September 2, 2022
This study investigates the evolutionary dynamics and function of progranulins (PGRNs) in lampreys, primitive vertebrates known for their regenerative abilities. Four genes encoding PGRNs were identif...
KEY FINDING: Four PGRN genes were identified in lampreys: one long form (Lr-PGRN-L) and three short forms (Lr-PGRN-S1, Lr-PGRN-S2, and Lr-PGRN-S3).
JOURNAL OF NEUROTRAUMA, 2012 • May 20, 2012
This study investigates the effects of mesenchymal stem cell (MSC) transplantation on macrophage activation and functional recovery in rats after spinal cord injury (SCI). The results demonstrate that...
KEY FINDING: Transplanted MSCs migrate to the injury site but do not turn into nerve or glial cells.
Int. J. Mol. Sci., 2023 • June 30, 2023
This study investigates the transcription patterns of neurotrophins and their receptors in the adult zebrafish spinal cord, using qPCR and in situ hybridization techniques. The results indicate that n...
KEY FINDING: Ngf mRNA is highly expressed in the spinal cord compared with the brain, and it is the most expressed transcript in the whole adult zebrafish spinal cord, compared to other neurotrophic factors.
Neural Regen Res, 2013 • January 1, 2013
This study investigated the role of ATP-activated mTOR signaling in the physiology and pathology of SCI, with a special focus on molecular targets of upstream, downstream, and inhibitor of mTOR kinase...
KEY FINDING: ATP promotes locomotor recovery after spinal cord injury in rats, as demonstrated by improved BBB scores in the ATP group compared to control groups.
Neural Regen Res, 2018 • August 1, 2018
The perspective piece emphasizes the complex and dynamic nature of the glial scar following spinal cord injury (SCI), moving beyond the outdated view of it being a simple barrier composed only of astr...
KEY FINDING: The glial scar is a multicellular structure comprising astrocytes, oligodendrocyte progenitor cells, microglia, macrophages, and fibroblasts/pericytes, all responding to the inflammatory environment after SCI.
Neural Regeneration Research, 2016 • May 1, 2016
This study investigates the effects of repetitive magnetic stimulation (rMS) on nerve regeneration after spinal cord injury (SCI) in rats. The study found that rMS improved the microenvironment of neu...
KEY FINDING: Repetitive magnetic stimulation reduced the number of apoptotic cells in the injured spinal cord.
The Journal of Neuroscience, 2002 • August 15, 2002
This study investigates the potential of olfactory mucosa (OM) transplantation to improve facial nerve regeneration in rats after nerve transection. The findings indicate that OM transplantation reduc...
KEY FINDING: OM transplantation improved vibrissae movement by up to 80% of control values, demonstrating enhanced motor performance.