Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 2,231-2,240 of 2,317 results
Molecular Medicine, 2022 • August 3, 2022
The study investigates the therapeutic potential of modulating neuronal activity in sensory and motor neurons, using opto- and chemogenetic stimulation, to regulate axonal growth after injury. Results...
KEY FINDING: Optogenetic stimulation of DRG neurons increases axonal growth in vitro.
Frontiers in Molecular Neuroscience, 2022 • September 7, 2022
This review focuses on the unique advantages of using zebrafish larvae as a model for studying spinal cord regeneration, emphasizing their optical transparency, simple anatomy, and complex locomotor b...
KEY FINDING: Spinal cord regeneration in zebrafish larvae is distinct from development, with injury-dependent responses such as immune cell infiltration and glial bridge formation.
Scientific Reports, 2019 • May 13, 2019
This study investigates the role of CRMP2 phosphorylation in axonal regeneration after optic nerve injury using CRMP2 knock-in mice, where CRMP2 phosphorylation at Ser522 is inhibited. The results ind...
KEY FINDING: Inhibition of CRMP2 phosphorylation suppresses microtubule depolymerization after optic nerve injury.
Expert Rev Neurother, 2017 • May 1, 2017
NPCs have the potential to replace damaged cells, promote neuroprotection, modulate neuroinflammation, and encourage axon regeneration after SCI. Challenges remain in maximizing the effectiveness and ...
KEY FINDING: NPC transplantation can restore structural integrity, produce therapeutic factors, and modulate neuroinflammatory processes.
BioMed Research International, 2016 • October 17, 2016
This study investigated the spatiotemporal changes of CGRP during spinal fusion to explore its role in bone regeneration. The results demonstrated that the early stage of normal spinal fusion is accom...
KEY FINDING: The density of CGRP reached its peak on the 21st day after the spinal fusion surgery in rats.
Exp Neurol, 2010 • August 1, 2010
The study investigated the effects of peripheral nerve grafts (PNG) and acidic fibroblast growth factor (αFGF) combined with step training on locomotor performance in rats with complete spinal cord tr...
KEY FINDING: PNG plus αFGF treatment resulted in a clear improvement in locomotor performance with or without step training.
The Journal of Neuroscience, 1999 • September 1, 1999
The study demonstrates that PSA-NCAM1 neural precursors, when transplanted into demyelinated lesions in the adult rat spinal cord, can efficiently remyelinate axons. This remyelination is achieved by ...
KEY FINDING: PSA-NCAM1 neural precursors can efficiently remyelinate demyelinated lesions in the adult rat spinal cord.
International Journal of Nanomedicine, 2023 • December 6, 2023
Spinal cord injury (SCI) treatment remains a significant clinical challenge, but neural tissue engineering offers a promising therapeutic approach through the implantation of functionalized electrocon...
KEY FINDING: Glial fibrosis and fluid-filled cysts impede electrical signaling and stimulus conduction in spinal cord tissue, hindering neural regeneration.
Frontiers in Cellular Neuroscience, 2019 • July 24, 2019
This study investigates the pro-neuroregenerative activity of ENDF1, a prenylated flavonoid, on dorsal root ganglion (DRG) neurons in the presence of extracellular matrix (ECM) growth inhibitors. The ...
KEY FINDING: ENDF1 promotes neurite regrowth of DRG neurons despite the presence of inhibitory ECM molecules.
Dev Dyn, 2021 • June 1, 2021
This study investigates the effects of CoCl2, a chemical that induces hypoxia and cellular stress, on axolotl tail regeneration, particularly in the context of romidepsin-induced regeneration inhibiti...
KEY FINDING: CoCl2 can partially rescue the inhibitory effect of romidepsin on tail regeneration when co-administered for 1 minute post-amputation (MPA).