Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 2,241-2,250 of 2,317 results
PNAS, 2007 • March 13, 2007
The study identifies pleiotrophin (PTN) as a neurotrophic factor upregulated in denervated distal nerve and muscle. Exogenous PTN enhances axonal regeneration and protects facial motor neurons from tr...
KEY FINDING: PTN mRNA is upregulated in denervated Schwann cells and muscle after axotomy, peaking at 7 days and returning to baseline by 3 months.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023 • August 10, 2023
The pathophysiological process of SCI is quite complex; nonetheless, the poor prognosis of patients with SCI may mainly be due to glial scar formation and irreversible neuron loss. SCI decreases the r...
KEY FINDING: SCI can decrease the phosphorylated (p)/total (t)‑GSK‑3β ratio, which leads to an increase in apoptosis, whereas treatment with GSK‑3 inhibitors can promote neurogenesis.
Journal of the Royal College of Physicians of London, 1994 • March 1, 1994
The review discusses the lack of spontaneous repair in the adult human central nervous system and explores strategies for promoting brain repair. These strategies include understanding developmental p...
KEY FINDING: Growth factors can protect neurons and glia from injury, promoting survival and potentially restoring normal cellular arrangements. Specifically, BDNF protects dopaminergic neurons, and bFGF protects hippocampal neurons from excitotoxic injury.
eLife, 2021 • September 29, 2021
This study performed single-cell transcriptional profiling of mouse DRG in response to peripheral and central axon injuries. The study provides a map of the distinct DRG microenvironment responses to ...
KEY FINDING: Each cell type in the DRG microenvironment responds differently to peripheral (sciatic nerve crush), dorsal root crush, and spinal cord injuries.
The Journal of Neuroscience, 1985 • June 1, 1985
This study demonstrates that certain neurons in the adult rat olfactory bulb (OB) can regrow axons along peripheral nerve grafts, indicating a regenerative capacity within the mammalian CNS. The resea...
KEY FINDING: OB axons extending along peripheral nerve grafts originate from mitral and tufted cells near the graft tip, not from smaller OB neurons.
Frontiers in Cellular Neuroscience, 2016 • January 20, 2016
Platelets are not restricted to haemostasis; they regulate inflammation, angiogenesis, and tissue repair. Neuroinflammation is relevant for CNS repair as it contributes to debris clearance and control...
KEY FINDING: Platelets accumulate in the subventricular zone (SVZ) vasculature upon demyelination, which is associated with enhanced survival of SVZ-resident neural stem cells (NSCs).
Stem Cell Research & Therapy, 2024 • November 22, 2024
Spinal cord injury (SCI) involves a continuous and dynamic cascade of complex reactions, with mitochondrial damage and dysfunction-induced energy metabolism disorders playing a central role throughout...
KEY FINDING: Mitochondrial transplantation (MT) reduces neuronal death and promotes axonal regeneration after spinal cord injury by regulating the MAPK/ERK and PI3K/Akt signaling pathways.
Biomaterials, 2019 • April 1, 2019
This review comprehensively reports technologies related to ex vivo models and lab-on-a-chip devices used to model regeneration in the peripheral and central nervous systems. It discusses the necessit...
KEY FINDING: Animal models often fail in clinical trials due to differences in healing mechanisms, injury replicability, and biological mismatches between humans and animals.
Stem Cells International, 2015 • December 14, 2015
Spinal cord injury (SCI) is a central nervous system- (CNS-) related disorder for which there is yet no successful treatment. The roles of both cell- and biomaterial-based therapies as single therapeu...
KEY FINDING: Stem cells from different origins have been tested for their ability to stimulate nerve regeneration and restore the neuronal circuitry when integrated in the injured site.
The Journal of Neuroscience, 2017 • November 8, 2017
This study investigates the effects of post-injury ErbB2 activation in Schwann cells (SCs) on dorsal root (DR) axon regeneration using a doxycycline-inducible transgenic mouse line. The results demons...
KEY FINDING: Post-injury induction of caErbB2 in SCs selectively hyperactivates denervated, but not innervated, SCs, increasing their proliferation and prolonging their dedifferentiation.