Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 2,251-2,260 of 2,317 results
Nat Protoc, 2017 • October 1, 2017
The study presents a detailed protocol for generating humanized bone marrow ossicles in mice to improve the study of human hematopoiesis and leukemia. This method involves in situ differentiation of b...
KEY FINDING: The ossicles allow for accelerated and superior engraftment of primary patient-derived acute myeloid leukemia (AML) and other hematologic malignancies such as myelofibrosis (MF) in mice.
eLife, 2020 • April 27, 2020
By intersecting chromatin accessibility data with single-cell transcriptomics, we find that NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to prol...
KEY FINDING: NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to proliferation.
Cellular and Molecular Life Sciences, 2022 • April 21, 2022
This study investigates the therapeutic potential of human dental apical papilla for spinal cord injury repair in a rat model. The findings demonstrate that the papilla reduces inflammation, promotes ...
KEY FINDING: The apical papilla reduced inflammation at the lesion site by decreasing the concentration of pro-inflammatory cytokines.
Frontiers in Physiology, 2021 • April 30, 2021
Traumatic spinal cord injury (SCI) initiates a complex cascade of pathological events, including vascular disruption and blood-spinal cord barrier (BSCB) breakdown, which exacerbate inflammation and t...
KEY FINDING: Blood vessel vascularization and remodeling after SCI are critical for SCI repair and functional recovery.
Stem Cell Rev and Rep, 2014 • May 8, 2014
This study investigates the guided migration of embryonic stem cell (ESC) derived presumptive motor neurons in an applied electric field (EF). The results showed that neural precursors migrated toward...
KEY FINDING: Neural precursors migrated toward the cathode pole of applied electric fields.
Neurospine, 2022 • December 1, 2022
Traumatic spinal cord injury (SCI) disrupts the spinal cord vasculature resulting in ischemia, amplification of the secondary injury cascade and exacerbation of neural tissue loss. Restoring functiona...
KEY FINDING: Five main therapeutic approaches to diminish hypoxia-ischemia and promote vascular repair were identified as (1) the application of angiogenic factors, (2) genetic engineering, (3) physical stimulation, (4) cell transplantation, and (5) biomaterials carrying various factor delivery.
Journal of Orthopaedic Surgery and Research, 2018 • September 28, 2018
This study explored the use of serum chemokine analysis to predict outcomes in non-union patients undergoing Masquelet therapy. The research identified CCL-3 and IFN-γ as potential biomarkers that, wh...
KEY FINDING: CCL-3 expression was significantly higher in non-responders (NR) compared to responders (R) during the study course (p = 0.002).
Bioactive Materials, 2022 • January 1, 2022
This study utilizes single-cell RNA sequencing to investigate the molecular mechanisms underlying MSC-mediated bone regeneration in different osteogenic microenvironments, specifically focusing on hyd...
KEY FINDING: HA scaffolds induce bone formation through a process similar to endochondral ossification, activating TGF-β, PTHrP, and BMP signaling pathways sequentially.
Dev Cell, 2021 • March 8, 2021
This study identified an essential EMT-driving gene regulatory network that regulates differential regenerative capacity between mammals and zebrafish after SC injury. At the center of glial bridging ...
KEY FINDING: Pro-regenerative zebrafish glia activate an epithelial-to-mesenchymal transition (EMT) gene program, distinguishing them from mammalian glia.
Exp Neurol, 2016 • September 1, 2016
The study examined whether eliminating myelin-associated inhibitors or activating intrinsic growth pathways could enhance NT-3-mediated regeneration of sensory axons through the dorsal root entry zone...
KEY FINDING: Loss of myelin inhibitory proteins showed modest enhancement of sensory axon regeneration.