Regenerative Medicine & Stem Cells Research

KEY FINDING: Transplantation of mesenchymal stem cells (MSCs) into the injured spinal cord can increase the number of M2 macrophages and reduce the number of M1 macrophages, leading to functional recovery in animal models.

KEY FINDING: Sox2 has been shown to reprogram astrocytes and NG2 glia into proliferating neuroblasts, which can further differentiate into mature neurons with additional treatments.

KEY FINDING: PTMs like phosphorylation, acetylation, detyrosination, and polyglutamylation modify tubulin, influencing microtubule functions essential for neurite outgrowth and growth cone guidance during nerve regeneration after SCI.

KEY FINDING: Transplantation of NSCs preconditioned with 1 ng/ml HMGB1 facilitated functional improvement of injured spinal cords, as indicated by improved Basso, Beattie and Bresnahan mean scores, reduced mechanical hypersensitivity, and decreased cold stimulation response.

KEY FINDING: CRISPRs are more effective and less toxic than TALENs for gene knockout in axolotls, achieving higher knockout penetrance.

KEY FINDING: GelMA hydrogel improved exercise ability in mice with SCI. Mice treated with GelMA hydrogel had markedly higher total scores and sub-scores on the BMS compared to the model group.

KEY FINDING: Targeted therapies show promise in enhancing myelin repair after SCI by modulating key molecules and signaling pathways.

KEY FINDING: bFGF acts through binding to tyrosine kinase FGF receptors on the cell membrane, triggering intracellular signaling pathways that initiate cell migration, proliferation, and differentiation.

KEY FINDING: dPDN grafts survive within the injured spinal cord and promote the ingrowth of axons to a similar extent as purified Schwann cell (SC) grafts.

KEY FINDING: ION-labeled MSCs migrate to the CP in an ischemic stroke model, as revealed by MRI and histological analysis.