Latest Research Summaries
Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,841-3,850 of 12,052 results
Cerium Oxide Nanoparticles Alleviate Neuropathic Pain by Modulating Macrophage Polarization in a Rat SCI Model
Journal of Pain Research, 2022 • October 25, 2022
Our study suggests that CONPs can relive the NP following SCI by promoting M2 macrophages polarization, which provides a novel insight for the treatment of SCI induced NP. Many researchers in the SCI ...
KEY FINDING: The synthesized CONPs were 6.8 ± 0.5 nm in size, presenting a cubic morphology.
Short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fMRI and qEEG: The first case report
Frontiers in Neurology, 2022 • October 25, 2022
This case report presents the first published case of short-term spinal cord stimulation (st-SCS) in a patient with disorders of consciousness (DOC). The patient, a 35-year-old male with severe trauma...
KEY FINDING: The patient improved from a vegetative state/unwakefulness syndrome to an emergence from a minimally conscious state after st-SCS treatment.
Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2
Cell Reports, 2022 • October 25, 2022
The study performs a genome-wide siRNA screen to identify RTN4R as a potent modifier of ataxin-2 levels. RTN4R knockdown or treatment with a peptide inhibitor is sufficient to lower ataxin-2 protein l...
KEY FINDING: Knockdown or peptide inhibition of RTN4R, the gene encoding the RTN4/NoGo-Receptor, lowers ataxin-2 protein levels in mouse and human neurons in vitro.
The Importance of Using Exosome‑Loaded miRNA for the Treatment of Spinal Cord Injury
Molecular Neurobiology, 2023 • October 24, 2022
Spinal cord injury (SCI) is a major traumatic disease of the central nervous system characterized by high rates of disability and mortality. Exosomes are membrane-bound vesicles with a diameter of onl...
KEY FINDING: Exosome-loaded miRNAs can aid the recovery of SCI in experimental mice, including the ability to promote neuronal recovery, inhibit apoptosis, promote axonal regeneration, modulate the inflammatory response, and promote angiogenesis, as well as to regulate microglia and macrophages.
SARS-CoV-2 IgG Levels Allow Predicting the Optimal Time Span of Convalescent Plasma Donor Suitability
Diagnostics, 2022 • October 22, 2022
The study analyzed 189 convalescent plasma (CP) donations from 66 donors to determine the optimal time span for CP donation based on anti-SARS-CoV-2 anti-S IgG antibody levels. It found a significant ...
KEY FINDING: There is a significant correlation between semi-quantitative SARS-CoV-2 IgG ratio values and in vitro antibody functionality.
Time is spine: What's over the horizon
Journal of Clinical Orthopaedics and Trauma, 2022 • October 22, 2022
The review emphasizes the importance of early surgical decompression in acute spinal cord injury (SCI) to reduce secondary damage and improve neurological outcomes. While evidence supports early inter...
KEY FINDING: Early surgical decompression (within 24 hours) is associated with improved neurological outcomes in SCI patients.
Falls on an inpatient rehabilitation spinal injuries unit: the characteristics, circumstances, and consequences
Spinal Cord, 2023 • October 22, 2022
This study aimed to describe the nature of falls and fallers in inpatient SCI rehabilitation, and identify factors associated with recurrent falls and consequential falls. The study found that 23% of ...
KEY FINDING: Nearly one quarter of spinal injuries unit inpatients experienced a fall, and almost a third of those experienced recurrent falls.
Thermo-sensitive hydrogel combined with SHH expressed RMSCs for rat spinal cord regeneration
Frontiers in Bioengineering and Biotechnology, 2022 • October 21, 2022
This study investigates a novel approach for treating spinal cord injuries (SCI) in rats by combining thermo-sensitive hydrogel with Sonic Hedgehog (SHH) expressed in rat bone-marrow derived mesenchym...
KEY FINDING: Transfection of SHH with cationic liposomes exhibited more effect in RMSCs than lipofectamine 2000.
Satisfaction with Surgical Procedures and Bladder Management of Chronic Spinal Cord Injured Patients with Voiding Dysfunction Who Desire Spontaneous Voiding
J. Pers. Med., 2022 • October 21, 2022
The study evaluated patient satisfaction with surgical procedures and bladder management in chronic SCI patients desiring spontaneous voiding. Initial satisfaction was generally high, especially with ...
KEY FINDING: Most patients were satisfied with their initial bladder outlet operation in facilitating spontaneous voiding, with TUI-BN and external sphincterotomy showing the highest satisfaction rates.
Current treatments after spinal cord injury: Cell engineering, tissue engineering, and combined therapies
Smart Medicine, 2022 • October 20, 2022
This review summarizes recent advances in cell engineering, tissue engineering, and combined therapies for spinal cord injury (SCI) treatment. It covers cell-based strategies with neuroprotective and ...
KEY FINDING: Recent advances in bioengineering have shown that therapies based on cells, biomaterials, and biomolecules are effective in spinal cord regeneration.