Browse our collection of 11,526 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,971-3,980 of 11,526 results
The Journal of Neuroscience, 2021 • October 13, 2021
This study investigates the role of astrocyte CD38 in myelin injury and regeneration, focusing on the impact of high-fat diets on oligodendrocytes and myelin integrity. The findings demonstrate that h...
KEY FINDING: High-fat diet consumption increases CD38 expression in astrocytes, leading to NAD1 depletion in the spinal cord.
GeroScience, 2021 • October 13, 2021
This correction addresses an error in the original publication concerning Figure 1 and its legend. The corrected figure presents data from experiments on aged and young rats, focusing on neuromuscular...
KEY FINDING: Aged rats show significant deficits in neuromuscular junction transmission.
Ann. Intensive Care, 2021 • October 12, 2021
This systematic review and meta-analysis examined weaning outcomes in mechanically ventilated patients with SCI, finding that approximately 63% of patients in the ICU could be weaned from the ventilat...
KEY FINDING: In ICU, the mean duration of mechanical ventilation was 27 days, with a weaning success rate of 63% and a mortality rate of 8%.
Occupational Therapy International, 2021 • October 12, 2021
This study examined the factors affecting the quality of life (QoL) of caregivers of individuals with spinal cord injuries (SCI) in Iran. The study found that caregiver QoL was significantly influence...
KEY FINDING: Moderate to highly significant negative correlations were observed between all domains of the WHOQoL scale and subscales of the CBS and the BDI-II.
Frontiers in Bioengineering and Biotechnology, 2021 • October 12, 2021
The central nervous system (CNS) has limited regeneration capacity, posing challenges for treating neurological disorders, but cell-based therapies offer a potential solution by delivering regenerativ...
KEY FINDING: Self-assembling peptides and hydrogels are potential candidates for treating neurological conditions like Alzheimer’s, Parkinson’s, spinal cord injury, stroke, and tumors.
Cureus, 2021 • October 11, 2021
This study evaluated the efficacy of platelet-rich plasma (PRP) compared to hydrogel dressing in treating pressure ulcers in spinal cord injury (SCI) patients. The study included 52 SCI patients with ...
KEY FINDING: Both PRP and hydrogel dressing significantly reduced the surface area and volume of pressure ulcers over the study period.
Front. Cell Dev. Biol., 2021 • October 11, 2021
This study used bioinformatics analysis to identify key eRNAs involved in spinal cord injury (SCI). The analysis revealed a regulatory network of transcription factors, eRNAs, target genes, immune ce...
KEY FINDING: Identified 21 DETFs, 24 DEeRNAs, and 829 DETGs in SCI patients compared to healthy controls.
Frontiers in Medical Technology, 2021 • October 8, 2021
This study explores the lived experience of individuals with spinal cord injuries using the ReWalk exoskeleton, revealing that successful integration depends on social and organizational processes, no...
KEY FINDING: The meaning of mobility extends beyond functional ability; standing and walking with the exoskeleton held socio-cultural significance linked to self-identity and life priorities. Physical mobility represents more than functional capacity.
Cell Death Discovery, 2021 • October 8, 2021
The study demonstrates that transplanting NSCs modified to express NGF under hypoxic conditions can improve recovery after SCI in rats. The 5HRE-NGF-NSCs group showed better locomotor recovery, increa...
KEY FINDING: 5HRE-NGF-NSCs effectively improve animal motor function.
Biology, 2021 • October 7, 2021
We have developed a novel moderately severe high-thoracic midline contusion SCI model that produces robust and clinically relevant impairment in cardiac and hemodynamic function whilst preserving 33 ±...
KEY FINDING: SCI produced a decrease in mean arterial pressure of 17 ± 3 mmHg (p < 0.001) and left ventricular contractility (end-systolic elastance) of 0.7 ± 0.1 mmHg/µL (p < 0.001).