Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 751-760 of 850 results
Adv. Sci., 2019 • February 27, 2019
Here, we introduce a biomimicking aligned fiber platform which allows the delivery of miRs both in vitro and in vivo in a sustained and nonviral manner. The easy incorporation of different miRs into t...
KEY FINDING: Enhanced gene-silencing is achieved in neurons as compared to conventional bolus delivery (p < 0.05).
International Journal of Nanomedicine, 2024 • May 13, 2024
This study investigates the effects of MgAl-LDH nanoparticles of varying sizes on the differentiation of mouse embryonic stem cells (mESCs) into neural progenitor cells (NPCs). The results demonstrate...
KEY FINDING: MgAl-LDH nanoparticles of 100 nm size significantly promote the differentiation of ESCs into NPCs compared to 30 nm and 50 nm sizes.
The Journal of Spinal Cord Medicine, 2013 • May 1, 2013
This systematic review analyzes studies using biomaterials to promote neuronal regeneration after spinal cord injury (SCI) in rodents. The review focuses on multimodal interventions combining biodegra...
KEY FINDING: Biomaterial-based interventions resulted in modest functional improvement in rodent models of SCI.
Biomedical Optics Express, 2022 • May 1, 2022
The study introduces a multi-wavelength photoacoustic time-frequency spectral analysis (MWPA-TFSA) method for simultaneous detection of changes in bone minerals, lipids, and bone marrow cluster size, ...
KEY FINDING: Osteoporotic bones exhibit a lower content ratio of hemoglobin (Hb) to lipid compared to normal bones, as indicated by the lower energy ratio of E760/E930 in MWPA measurements.
Journal of Nanobiotechnology, 2022 • July 1, 2022
This study investigates the therapeutic effect of huc-MSCs-derived exosomes on CFA-induced inflammatory pain in mice. The exosomes were administered intrathecally, and behavioral tests were conducted ...
KEY FINDING: Huc-MSCs-derived exosomes alleviated mechanical allodynia and thermal hyperalgesia in CFA-induced inflammatory pain model.
Asian J Neurosurg, 2024 • September 3, 2024
This systematic review explores the use of 3D printing (3DP) in treating spinal cord injuries (SCIs), assessing its cost, efficacy, safety, and technological constraints. The review analyzed 11 studie...
KEY FINDING: 3DP technologies are showing positive results in treating SCIs and have the potential to improve both surgical and non-surgical treatments.
Materials Today Bio, 2023 • March 14, 2023
This study introduces a bioactive molecule-laden PLGA composite (PME2/PN) designed for multi-modulation of bone fusion, addressing limitations in current bone substitute technologies. The PME2/PN comp...
KEY FINDING: The PME2/PN composite significantly improved osteogenic and angiogenic gene expression, crucial for bone fusion.
Bioactive Materials, 2021 • March 9, 2021
The study demonstrates that cyclic mechanical loading can modulate the immunoinflammatory microenvironment and stimulate osteogenic differentiation of MSCs seeded on 3D scaffolds. ECM-based scaffolds ...
KEY FINDING: Mechanical loading downregulated inflammatory mediators (IL1B and IL8) and upregulated osteogenic markers (ALP and COL1A1) in MSCs seeded on scaffolds.
Smart Medicine, 2022 • October 20, 2022
This review summarizes recent advances in cell engineering, tissue engineering, and combined therapies for spinal cord injury (SCI) treatment. It covers cell-based strategies with neuroprotective and ...
KEY FINDING: Recent advances in bioengineering have shown that therapies based on cells, biomaterials, and biomolecules are effective in spinal cord regeneration.
Frontiers in Neurology, 2018 • May 22, 2018
This study details the design and sizing of a guiding device for precision grafting of peripheral nerves in complete thoracic spinal cord injury (SCI). The device's design and sizing are compared to a...
KEY FINDING: A set of seven guiding device sizes can accommodate the range of human thoracic spinal cord sizes (T2-T12) with acceptable error.