Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 761-770 of 850 results
Journal of Nanobiotechnology, 2025 • January 22, 2025
This study investigates the application of decellularized tissue matrices (DSCM) hydrogels functionalized with extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) for spinal cor...
KEY FINDING: DSCM@EVs promote NSC differentiation into neurons and suppress astrocyte formation, alleviating SCI in mice.
Cells, 2022 • March 28, 2022
This study combined mesenchymal stromal cells (MSCs) and a nanofiber-hydrogel composite (NHC) to assess their repair effects in the contused spinal cord in adult rats. The data support further study in...
KEY FINDING: Treatment with MSC-NHC or NHC alone significantly attenuated early macrophage infiltration in the contusion compared to MSC-PBS, indicating a reduced initial inflammatory response.
International Journal of Molecular Sciences, 2020 • May 4, 2020
Neurodegenerative disorders (NDs) are a growing problem worldwide, and current treatments are limited to addressing symptoms rather than underlying mechanisms. Biomaterials offer a promising therapeut...
KEY FINDING: Hydrogels serve as effective scaffolds for stem cell culture and differentiation, while also acting as carriers for growth factors that support cell growth.
Journal of Nanobiotechnology, 2024 • August 22, 2024
This study investigates the role of spinal cord-derived microvascular endothelial cells (SCMECs) in promoting axon growth after spinal cord injury (SCI). The researchers found that SCMECs promote axon...
KEY FINDING: SCMECs promote axon outgrowth in a non-contact fashion by downregulating miR-323-5p expression in neurons.
Journal of Materials Science: Materials in Medicine, 2023 • May 16, 2023
This document is an author correction to a previously published article. The corrections involve author affiliations, names, and contact information. The original article has been updated with these c...
KEY FINDING: The original article contained mistakes regarding author affiliations and names.
Frontiers in Bioengineering and Biotechnology, 2022 • May 13, 2022
This editorial highlights the growing need for effective strategies to repair musculoskeletal tissue, especially tendon injuries and chronic tendinopathies. The special issue of Frontiers in Bioengine...
KEY FINDING: Pathological inflammation differs from reparative inflammation, and immunomodulatory therapies could be effective if timed correctly.
Regenerative Biomaterials, 2020 • January 1, 2020
The study successfully fabricated SC-NSC core–shell fibers using a coaxial nozzle, encapsulating SCs in an alginate hydrogel shell and NSCs in the core. SCs in the shell exhibited higher expression of...
KEY FINDING: Schwann cells (SCs) encapsulated in the alginate hydrogel shell expressed more genes of neurotrophic factors compared to those cultured in petri dishes, indicating enhanced neurotrophic support.
Biophysical Reviews, 2024 • October 5, 2023
New optical techniques in neuroscience advance understanding of neurological conditions. They show potential in unraveling processes and evaluating therapies for spinal cord injury, peripheral nerve i...
KEY FINDING: Coherent Raman scattering and third harmonic generation enable label-free visualization of myelin sheaths. Combining these with two-photon excited autofluorescence and second harmonic generation allows comprehensive tissue visualization.
Journal of NeuroEngineering and Rehabilitation, 2012 • June 19, 2012
This study explores the feasibility of using descending signals in the spinal cord above the injury site to generate volitional motor control signals. The study demonstrated that chronic recordings up...
KEY FINDING: Chronic recordings can be made from the descending tracts of the rat spinal cord for up to 3 months with relatively small changes in signal characteristics over time.
Adv Funct Mater, 2020 • January 3, 2020
3D printing offers a promising approach to neural regeneration by enabling the creation of patient-specific scaffolds with precise control over geometry, mechanics, and biology. The development of 3D ...
KEY FINDING: 3D printing offers vital features such as coupling with 3D imaging, robotics-based biomanufacturing, compatibility with multiple material sets, and rapid prototyping.