Biomedical Research

KEY FINDING: Multifunctional magnetic core−shell nanoparticles (MCNPs) facilitate efficient siRNA transfection into primary rat NSCs (rNSCs) with minimal cytotoxicity and the ability to track transplanted cells using MRI.

KEY FINDING: Intervertebral discs are complex structures comprised of the annulus fibrosus, nucleus pulposus, and vertebral endplates, each contributing to the disc's structural and mechanical integrity.

KEY FINDING: Skeletal muscle can be reinnervated by a number of axons multiple times its initial physiological innervation.

KEY FINDING: DeepScreen demonstrates high accuracy in assessing the efficacy of drugs and nanoformulated drug systems, achieving accuracies of 0.851, 0.864, and 0.908 in testing mixed cells, HEpG2, and A549 cells, respectively.

KEY FINDING: The release rate of payloads from the hydrogels can be customized by selecting azidoacids of varying lengths, thereby controlling ester hydrophobicity.

KEY FINDING: The linear model parameters clearly influence either simulated force magnitude or speed properties, consistent with previous parameter definitions.

KEY FINDING: Good control of isometric force was achieved in both degrees of freedom, with RMS errors less than 10% of the force range in seven experiments.

KEY FINDING: The platform combines a CDP device with low-cost interfaces, such as the Nintendo Wii Balance Board and the Microsoft Kinect.

KEY FINDING: Hydrogels can simulate the ECM in the cystic cavity to achieve the better therapeutic effect.

KEY FINDING: Both scaffold groups showed similar structural alteration upon immersion, with an increase in surface area and scaffold volume, and a decrease in density.