Biomedical Research

KEY FINDING: Aligned 3D porous PU scaffolds were successfully prepared using a green process, demonstrating a more suitable structure for anisotropic tissue repair compared to random porous scaffolds.

KEY FINDING: MnO2@TMNP effectively binds inflammatory factors and nerve growth factors, inhibiting inflammation-induced apoptosis and nerve ingrowth.

KEY FINDING: The xanthohumol-loaded PLGA scaffolds exhibited anti-inflammatory properties in vitro, reducing the expression of inflammatory cytokines (IL-1β and TNF-α) in macrophages.

KEY FINDING: Electrode shape has little effect on the induced electric field distribution within the spinal cord.

KEY FINDING: PPT NMs effectively mitigated LPS-stimulated cell apoptosis, in a dose-dependent manner, suggesting an anti-apoptotic effect.

KEY FINDING: Participants with stroke and SCI showed good compliance with the automated FES device, completing a high number of repetitions during training sessions.

KEY FINDING: COL-HEP/GF scaffolds induce a tight but subtle control over cell signaling and extracellular matrix organization.

KEY FINDING: EVAnalyzer enables the automated and quantitative analysis of single vesicles from imaging data, using a robust protocol for capture, labeling, and fluorescent imaging of EVs.

KEY FINDING: Hydrogen sulfide (H2S) has anti-inflammatory and anti-apoptotic effects and can protect the spinal cord. It reduces oxidative stress and promotes axon growth.

KEY FINDING: The hybrid controller is a feasible approach for exoskeleton devices, combining the benefits of end-point control in shaping desired stiffness and joint control to promote correct angular changes.