Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 181-190 of 211 results
PM R, 2017 • August 1, 2017
This study investigated the prevalence and etiology of hypogonadism in young men with chronic SCI, finding a significantly higher prevalence compared to non-SCI men. Risk factors identified include mo...
KEY FINDING: Hypogonadism was more common in men after SCI than in a matched cohort of similarly-aged men without SCI (25%, SCI vs 6.7%, non-SCI, P<.001).
Environmental Epigenetics, 2016 • September 16, 2016
The review summarizes the evidence linking BPA exposure to obesity and the involvement of epigenetic mechanisms. Early-life exposure to BPA is particularly effective in predisposing individuals to wei...
KEY FINDING: Early-life exposure to BPA can predispose individuals to weight gain and metabolic disturbances such as obesity and diabetes.
J Neurotrauma, 2021 • February 1, 2021
This study investigates the effects of low-dose, site-directed estrogen delivery via nanoparticles on spinal cord injury (SCI) in rats. The researchers hypothesized that this method would reduce infla...
KEY FINDING: Site-directed estrogen delivery reduced lesion size, reactive gliosis, and glial scar formation compared to controls.
Cell Regeneration, 2021 • March 15, 2021
This study investigates the expression and function of the melanocortin 4 receptor (MC4R) in mouse limb and digit regeneration. It utilizes Mc4r-gfp mice to track MC4R expression during development an...
KEY FINDING: Mc4r expression in the mouse limb and digit is closely related to nerve tissues.
The Journal of Spinal Cord Medicine, 2018 • January 1, 2018
This randomized clinical trial evaluated the impact of a 7-month nutrition education program on lipid profiles and body weight in Iranian patients with spinal cord injury (SCI). The results indicated ...
KEY FINDING: The nutrition education program did not significantly affect total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), or high-density lipoprotein cholesterol (HDL-C) levels in patients with SCI.
Spinal Cord, 2018 • March 1, 2018
This study aimed to determine the optimal GnRH dose to identify hypothalamic-pituitary-gonadal axis dysfunction in men with SCI by comparing gonadotropin responses to different GnRH doses (10, 50, 100...
KEY FINDING: Lower doses of GnRH did not improve the ability to identify clinical dysfunction of the hypothalamic-pituitary-gonadal axis.
PM R, 2018 • April 1, 2018
This study examined the relationship between testosterone levels and cardiometabolic risk factors in young men with chronic spinal cord injury (SCI). It found that low testosterone levels are associat...
KEY FINDING: Men with low free testosterone had significantly higher Framingham Risk Scores, indicating a greater risk of cardiovascular events.
Frontiers in Immunology, 2023 • September 8, 2023
This study comprehensively analyzed gene expression in patients with PSID after major abdominal surgery to identify hub genes associated with immune and metabolic alterations. The analysis revealed si...
KEY FINDING: Identified 512 upregulated and 254 downregulated DEGs in patients with PSID compared with controls, significantly associated with immune- and metabolism-related biological processes and pathways.
The Journal of Spinal Cord Medicine, 2016 • July 1, 2016
This study aimed to identify the prevalence of obesity in individuals with chronic spinal cord injury (SCI), track changes in body mass index (BMI) over a three-year period, and determine the impact o...
KEY FINDING: The majority of participants with chronic SCI were overweight (23%) or obese (44%) according to the SCI adjusted BMI classification.
The Journal of Comparative Neurology, 2012 • February 8, 2012
This study aimed to evaluate the effects of post-SCI administration of 17b-estradiol on functional recovery and histopathology in a cervical model of SCI. The researchers found that post-SCI administr...
KEY FINDING: Post-SCI administration of 17b-estradiol decreased neuronal loss in the ventral horn, suggesting a neuroprotective effect.