Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 191-200 of 211 results
Neural Regeneration Research, 2017 • March 1, 2017
The study aimed to determine whether a relationship exists between estrogen and NMDAR1 in peripheral nerve pain using a rat model of chronic sciatic nerve constriction injury. Rats administered estrad...
KEY FINDING: Estrogen administration significantly reduced mechanical and thermal pain thresholds in rats with chronic constriction of the sciatic nerve.
PPAR Research, 2018 • June 21, 2018
This study evaluated the effect of simultaneous activation of PPAR-γ and PKA on promoting locomotor recovery in SD rats, the expression of the inflammatory factor NF-κB, survival of mature neurons, an...
KEY FINDING: The combination of rosiglitazone and forskolin resulted in better locomotor recovery in SD rats after SCI compared to either treatment alone.
BioMed Research International, 2017 • August 30, 2017
This study investigated the relationship between liver adiposity, measured by MRI, and metabolic profile in men with chronic spinal cord injury (SCI). The results showed that increased liver fat was a...
KEY FINDING: Fat signal fraction (FSF) in the liver was positively related to triglycerides (TG), non-HDL-C, fasting glucose, and HbA1c, indicating a link between liver fat and poorer lipid and glucose control.
Neural Regeneration Research, 2014 • December 1, 2014
Melatonin has been shown to diminish edema in rats. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i...
KEY FINDING: Melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord after spinal cord injury.
PM R, 2018 • March 1, 2018
This study investigated the associations between plasma leptin and adiponectin levels and pulmonary function in individuals with chronic spinal cord injury (SCI). The results showed a significant inve...
KEY FINDING: There was a statistically significant inverse relationship between plasma leptin with FEV1 and FVC.
European Journal of Sport Science, 2024 • November 1, 2024
This study assessed glycemic control in elite Para cyclists using continuous glucose monitoring (CGM). The athletes spent most of their time in euglycemia, with mild hyperglycemia after meals and duri...
KEY FINDING: Para cyclists generally maintain blood glucose levels within the normal range (euglycemia) most of the time.
The Journal of Spinal Cord Medicine, 2018 • January 1, 2018
SCI results in reduced metabolism, leading to adipose tissue accumulation and neurogenic obesity. Neurogenic obesity causes chronic, systemic inflammation through the overexpression of proinflammatory...
KEY FINDING: Obesity in SCI leads to chronic inflammation due to proinflammatory adipokines released from excess adipose tissue.
PLoS ONE, 2015 • February 23, 2015
The study examined serum lipid concentrations in subjects with traumatic SCI in relation to the degree of neurological involvement and time since injury, comparing them with values from a reference sa...
KEY FINDING: Cases without preserved motor function (AIS A or B) had lower total and HDL cholesterol than the others.
Scientific Reports, 2024 • November 25, 2024
This study examined the potential of GnRH and GH treatments to promote neurotrophic and synaptic recovery in ovariectomized rats with thoracic SCI. The results showed that chronic administration of Gn...
KEY FINDING: GnRH and GH treatments upregulate the expression of neurotrophic and synaptogenic activity genes in rats with SCI.
Journal of International Medical Research, 2023 • September 1, 2023
This study aimed to investigate inflammatory cytokine expression profiles in the aqueous humor (AH) of diabetic cataract (DC) patients. The multiplexed antibody assay revealed that the expression leve...
KEY FINDING: Expression levels of IL-6, sIL-6R, IL-17A, IL-8, MCP-1, TNF-b, RANTES, TIMP-1, and TIMP-2 were significantly higher in DC patients compared with ARC patients.