Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 141-150 of 620 results
Int. J. Mol. Sci., 2015 • April 9, 2015
This study measured serum cytokine levels in 40 acute traumatic SCI patients over 12 weeks to assess their impact on neurological outcome. The study found that specific cytokines (TNFα, IL-1β, IL-6, I...
KEY FINDING: TNFα, IL-1β, IL-6, IL-8, and IL-10 concentrations were significantly higher in patients without neurological remission.
Brazilian Journal of Infectious Diseases, 2016 • October 18, 2016
This retrospective study evaluated the effectiveness of different antibiotic protocols in preventing urinary tract infections (UTIs) in patients with neurogenic bladder undergoing botulinum toxin A (B...
KEY FINDING: The study found a low overall rate of symptomatic UTIs (1.8%) among patients receiving botulinum toxin A injections for neurogenic bladder.
Oncotarget, 2016 • October 20, 2016
The goal of the research reported here was the identification of potential serological biomarkers associated with the GBS. To address this objective, a quantitative proteomics approach was used to cha...
KEY FINDING: The results showed that Piccolo, a protein that is essential in the maintenance of active zone structure, constitutes a potential serological correlate of recovery from GBS.
The Journal of Spinal Cord Medicine, 2016 • January 1, 2016
A 66-year-old male with quadriplegia developed myoclonus, asterixis, and tremor after being treated with high-dose trimethoprim-sulfamethoxazole (TMP-SMX) for Pneumocystis jiroveci pneumonia (PJP). Sy...
KEY FINDING: High dose TMP-SMX can induce reversible myoclonus, asterixis, and tremor.
PLOS ONE, 2015 • September 11, 2015
This study investigates the anti-inflammatory role of IL-27 in zymosan-induced peritonitis, focusing on its effects on neutrophil recruitment. The results demonstrate that IL-27 reduces neutrophil acc...
KEY FINDING: IL-27 treatment reduces neutrophil accumulation in the peritoneal cavity in a zymosan-induced peritonitis model.
Cell Death & Disease, 2021 • April 29, 2021
This study analyzed human umbilical-cord-derived MSCs from 32 donors and found donor-dependent variations in cell proliferation and immune modulatory functions, potentially explaining inconsistent cli...
KEY FINDING: Human umbilical cord-derived MSCs from 32 donors showed donor-dependent variations in proliferation and immune modulation capabilities.
Journal of Neuroinflammation, 2015 • August 18, 2015
This study investigates the role of 14-3-3 γ in glial cells during autoimmune demyelination using a knockout mouse model of EAE. The findings indicate that 14-3-3 γ is expressed in oligodendrocytes an...
KEY FINDING: 14-3-3 γ mRNA expression increases in the spinal cord during the late chronic phase of MOG-EAE.
Spinal Cord Series and Cases, 2016 • July 7, 2016
This case report describes the challenges of managing CRE infections in a spinal cord injury rehabilitation unit, highlighting the risk factors, treatment complexities, and impact on patient rehabilit...
KEY FINDING: A patient with paraplegia developed a CRE urinary tract infection and sepsis one month post-injury, requiring treatment with colistin.
Brain, 2016 • January 10, 2016
This study investigates the link between spinal cord injury (SCI), a weakened immune system (SCI-IDS), and increased susceptibility to pneumonia, focusing on the impact of injury level on this relatio...
KEY FINDING: High thoracic spinal cord injuries in mice significantly increased bacterial load in the lungs, indicating increased susceptibility to pneumonia.
Neurochemical Research, 2023 • September 12, 2022
This study investigates the context-dependent effects of the complement peptide C3a on primary mouse astrocytes under different conditions: naive, after chemical ischemia, and after exposure to lipopo...
KEY FINDING: C3a down-regulated the expression of Gfap, C3 and Nes in astrocytes after ischemia, suggesting a reduction in reactive astrocyte markers in this context.