Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 191-200 of 620 results
Frontiers in Immunology, 2018 • October 11, 2018
This study investigates autoantibodies (AAbs) in patients with spinal cord injury (SCI). The key finding is that AAbs against damaged spinal cord tissue are already present in healthy individuals and ...
KEY FINDING: Autoantibodies against damaged spinal cord are detectable in the sera of normal subjects.
Anesthesiology, 2019 • February 1, 2019
This study demonstrates that morphine administration following a tibial fracture in mice exacerbates nociceptive sensitization and functional impairment, prolonging recovery. The adverse effects of mo...
KEY FINDING: Morphine treatment after tibial fracture exacerbates mechanical nociceptive sensitization and prolongs its duration.
The Journal of Neuroscience, 2019 • February 13, 2019
The study demonstrates that repeated social defeat (RSD) stress promotes a neuroinflammatory environment in the spinal cord, leading to increased pain sensitivity (mechanical allodynia) in mice. Micro...
KEY FINDING: Repeated social defeat (RSD) stress increases mechanical allodynia (pain sensitivity) in mice.
Tissue Eng Regen Med, 2017 • January 17, 2017
This study investigates the therapeutic effects of LLLI on motor function recovery and its mechanisms in rats with SCI. The results demonstrate that transcutaneous LLLI modulates inflammatory mediator...
KEY FINDING: LLLI with 0.4 J and 0.8 J led to a significant improvement in motor function compared to sham LLLI.
Spinal Cord, 2019 • February 27, 2019
This study aimed to determine whether probiotic therapy with Lactobacillus reuteri RC-14+Lactobacillus GR-1 (RC14-GR1) and/or Lactobacillus rhamnosus GG+Bifidobacterium BB-12 (LGG-BB12) are effective i...
KEY FINDING: RC14-GR1 did not significantly reduce the risk of UTI compared to placebo (HR 0.67; 95% CI: 0.39–1.18; P = 0.17).
Journal of Neuroinflammation, 2019 • April 8, 2019
This study investigates how macrophage migration inhibitory factor (MIF) influences the production of prostaglandin E2 (PGE2) in astrocytes after spinal cord injury (SCI). The results demonstrate that...
KEY FINDING: MIF and COX2 protein levels increased synchronously after spinal cord injury in rats. Blocking MIF reduced COX2 and mPGES-1 expression, leading to decreased PGE2 production.
Journal of Neuroinflammation, 2019 • May 8, 2019
The study investigated the use of mineral-coated microparticles (MCMs) for sustained delivery of interleukin-10 (IL-10) to treat spinal cord injury (SCI) in rats. Results showed that MCMs+IL-10 treatm...
KEY FINDING: MCMs effectively delivered IL-10 to the injury site, resulting in elevated IL-10 levels and suppressed inflammatory cytokines.
Advances in Urology, 2019 • April 2, 2019
This review addresses the challenges in diagnosing and managing UTIs in adult neurogenic lower urinary tract dysfunction (ANLUTD) patients using intermittent catheterization (IC) in community settings...
KEY FINDING: The study highlights the lack of a universally accepted definition of UTIs, which complicates both clinical practice and research efforts in the field of neuro-urology.
Journal of Medical Case Reports, 2019 • April 30, 2019
This case report details a 74-year-old man who developed Aspergillus terreus spondylodiscitis following an abdominal stab wound, a previously unreported occurrence. The patient's condition was charact...
KEY FINDING: Aspergillus terreus spondylodiscitis can occur following a penetrating abdominal injury, likely due to direct inoculation of the fungus.
PLoS ONE, 2012 • June 20, 2012
This study investigated the role of TNFa in modulating spinal plasticity and its impact on spinal learning after injury. Using a rat model of instrumental learning, the researchers explored how interm...
KEY FINDING: Intermittent stimulation increases TNFa protein expression in the spinal cord.