Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 491-500 of 620 results
Journal of Orthopaedic Surgery and Research, 2025 • February 10, 2025
This study retrospectively analyzed 22 patients with severe post-tubercular kyphosis (PTK) who underwent modified posterior vertebral column resection (mPVCR). The results demonstrated significant imp...
KEY FINDING: The modified PVCR technique resulted in a significant improvement in kyphosis angle (KA) from 129.5° to 43.7° postoperatively.
The Journal of Spinal Cord Medicine, 2017 • January 1, 2017
This case report describes a 40-year-old man with complete T4 SCI and multiple pressure ulcers who presented with seizure and altered conscious level, eventually diagnosed with a deep-seated sacral ab...
KEY FINDING: A deep-seated sacral abscess can present with unusual symptoms like seizures and altered consciousness in SCI patients.
Journal of Family Medicine and Primary Care, 2017 • July 1, 2017
This study evaluated the reliability and validity of urine dipstick tests performed by SCI patients for UTI screening, compared to the NIDRR criteria. The interrater reliability of the combined leukoc...
KEY FINDING: The interrater reliability of combined leukocyte esterase and nitrite urine dipstick test was moderate agreement.
Neurotherapeutics, 2024 • May 1, 2024
This study investigated the effects of selective PDE4B and PDE4D inhibitors on SCI pathology in mice. The PDE4D inhibitor Gebr32a improved functional and histopathological outcomes after SCI, similar ...
KEY FINDING: The PDE4D inhibitor Gebr32a improved functional recovery after SCI, even when administered 2 days post-injury.
Journal of Neuroinflammation, 2022 • March 1, 2022
This study investigates the role of NLRP3 inflammasome activation in sciatic nerve injury, focusing on motoneurons, microgliosis, and regeneration. The central reaction to sciatic nerve injury begins ...
KEY FINDING: NLRP3 inflammasome components are markedly upregulated in the L4–L5 segments of the spinal cord in the first 3 days after sciatic nerve injury.
Neural Regeneration Research, 2023 • September 1, 2023
The review focuses on the role of matrix metalloproteases (MMPs) in spinal cord injury (SCI) and the potential of MMP inhibitors as a therapeutic strategy. MMPs contribute to several detrimental proce...
KEY FINDING: MMP-9 and MMP-2 are upregulated after SCI, contributing to BSCB breakdown, inflammation, and apoptosis.
The Journal of Neuroscience, 2021 • April 14, 2021
The study investigates how to harness the beneficial aspects of neuroinflammation to promote regeneration, focusing on macrophages and microglia. It reveals that the combination of LPS (a pro-inflamma...
KEY FINDING: The combination of LPS and regulatory IL4 and IL13 signaling in macrophages and microglia produces a reparative phenotype devoid of pro-inflammatory neurotoxic features.
Front. Cell. Neurosci., 2016 • June 28, 2016
The study investigated the impact of TH2-polarized systemic inflammation, characteristic of allergies, on the neurogenic niche in the hippocampus using a grass pollen allergy model in mice. The resear...
KEY FINDING: Allergic sensitization led to a reduction in the number of Iba1+ microglia in the granular layer (GL) and subgranular zone (SGZ) of the hippocampal dentate gyrus.
AGING, 2023 • February 1, 2023
This study investigated the impact of short-term platelet depletion on Alzheimer's disease neuropathology in APP-PS1 mice. The researchers found that platelet depletion in female APP-PS1 mice augmente...
KEY FINDING: Platelet depletion in APP-PS1 female mice shifted amyloid plaque size distribution towards bigger plaques and increased neuritic dystrophy in the hippocampus.
The EMBO Journal, 2023 • February 17, 2023
This study identifies IFITM1 as a key repressor of brain metastatic colonization in lung cancer. Loss of IFITM1 promotes brain colonization, while high IFITM1 expression activates microglia and enhanc...
KEY FINDING: Loss of IFITM1 promotes brain colonization of human lung cancer cells, identified through in vivo genome-wide CRISPR-Cas9 screening.