Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 571-580 of 620 results
Exp Neurol, 2020 • January 1, 2020
This review addresses how SCI changes the physiological interplay between the spinal cord, the gut and the immune system. A suspected culprit in causing many of the pathological manifestations of impa...
KEY FINDING: SCI leads to gut dysbiosis, characterized by changes in the composition and abundance of gut bacteria, such as a decrease in Bacteroidales and an increase in Clostridiales.
Journal of Neuroinflammation, 2024 • November 18, 2024
This study reveals CD22 as a key molecular switch governing the beneficial effects of microglia and Gr-1+ myeloid cells in NMOSD pathology. CD22 blockade exacerbated NMOSD lesions, astrocyte loss, and...
KEY FINDING: CD22 is expressed in B cells, neutrophils, monocytes, and microglia-derived exosomes in human peripheral blood from NMOSD patients and controls, as well as in a mouse model of NMOSD.
J. Clin. Med., 2022 • April 11, 2022
The study investigated the effects of pre- and postconditioning with a TLR3 agonist (poly(I:C)) or shock wave therapy (SWT) on spinal cord ischemia (SCI) in cultured SHSY-5Y cells. TLR3 activation wit...
KEY FINDING: TLR3 activation via poly(I:C) significantly reduced apoptotic markers in both pre- and postconditioning, with preconditioning yielding more favorable results due to additional suppression of TLR4 signaling.
Journal of Immunology Research, 2021 • September 24, 2021
This study investigates the impact of various stress conditions on the release of extracellular vesicles (EVs) by Trypanosoma cruzi trypomastigotes. The research examines how factors like temperature,...
KEY FINDING: Low temperatures (4°C) and acidic conditions (pH 5.0) increase EV release by Trypanosoma cruzi trypomastigotes.
Eur J Neurol, 2024 • August 4, 2024
This study investigates noncompressive myelopathy as a rare but severe complication of community-acquired bacterial meningitis, identifying seven cases from a nationwide cohort and reviewing 15 additi...
KEY FINDING: Noncompressive myelopathy was reported in 0.23% of community-acquired bacterial meningitis cases.
Frontiers in Cell and Developmental Biology, 2022 • April 13, 2022
The editorial provides an overview of the recent advancements in parasitic disease control by utilizing novel tools and methodologies developed in genomic, epigenomic, proteomics, and metabolomics res...
KEY FINDING: High-quality genome assembly of Moniezia expansa reveals potential target molecules for treating parasitic diseases through the identification of specific fatty acid metabolism and reproductive stem cell regulatory networks.
J Spinal Cord Med, 2010 • June 1, 2010
The study aimed to determine the incidence and etiology of fever and the risk factors related to fever in adults with SCI at the rehabilitation stage. A high rate of fever was seen in patients with SC...
KEY FINDING: The incidence of fever during rehabilitation was 47.7%.
Journal of Biomedical Optics, 2011 • October 4, 2011
This study investigates myelin integrity in mice with relapsing experimental autoimmune encephalomyelitis (EAE) using coherent anti-Stokes Raman scattering (CARS) microscopy. The research demonstrates...
KEY FINDING: Paranodal myelin retraction is an early event in relapsing experimental autoimmune encephalomyelitis (EAE), occurring at the onset of the disease and at the borders of acute demyelinating lesions.
Molecular Pain, 2011 • January 5, 2011
This study investigates whether a preconditioning nerve lesion influences pain sensation and neuroinflammation following a subsequent peripheral nerve injury. The results show that a preconditioning c...
KEY FINDING: A preconditioning crush injury to the tibial nerve significantly attenuated mechanical allodynia and thermal hyperalgesia following partial sciatic nerve ligation (PSNL).
Cell Death and Disease, 2022 • May 12, 2022
This study used single-cell RNA sequencing to analyze immune cell dynamics after spinal cord injury (SCI) in mice, revealing the heterogeneity of immune cells and the repopulation of microglia. The re...
KEY FINDING: Microglia repopulation after SCI is primarily derived from residual microglia, not from nestin+ stem cells.