Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 581-590 of 620 results
Journal of Inflammation Research, 2025 • February 17, 2025
This study investigated the synergistic effects of combining Shinbaro and celecoxib in a mouse model of CFA-induced inflammatory pain. The results demonstrated that the combination therapy effectively...
KEY FINDING: The combination of Shinbaro and celecoxib synergistically reduced mechanical hyperalgesia and paw edema in mice with CFA-induced inflammatory pain.
The Journal of Spinal Cord Medicine, 2011 • January 1, 2011
The study investigates the current clinical practice in treating urinary tract infections (UTIs) in persons with spinal cord injury (SCI) in German-speaking SCI centers and compares it with current gu...
KEY FINDING: Substantial differences exist among SCI centers in the indications for UTI treatment, medications used, and treatment duration, often deviating from existing guidelines.
Journal of Neuroinflammation, 2008 • October 15, 2008
The study investigates the effect of TMEV infection on inflammation and neurogenesis in the SVZ, a key area for brain repair. Results indicated that forebrain CD45+ cell activation precedes spinal cor...
KEY FINDING: CD45+ cell activation occurs early in the forebrain after TMEV infection, with the SVZ showing the most consistent activation.
Stem Cells Translational Medicine, 2025 • February 11, 2025
The study investigates how different immunomodulatory strategies (genetic immunodeficiency vs. pharmacological immunosuppression) affect the survival, integration, and gene expression of transplanted ...
KEY FINDING: X-SCID rats exhibited significantly higher retention of transplanted NPCs compared to both Wistar and RNU rats, indicating that both T and B cells play crucial roles in the rejection of xenografted human NPCs.
PLOS Neglected Tropical Diseases, 2022 • December 5, 2022
The study analyzed polymorphisms in drug resistance-related genes of P. ovale spp. in samples from travelers returning to China from Africa. High frequencies of S58R and S113N/T mutations were observe...
KEY FINDING: Two podhfr mutations, S58R and S113N/T, were detected in P. ovale curtisi with high/moderate frequencies.
Cellular & Molecular Biology Letters, 2022 • March 14, 2022
The study investigates the therapeutic potential of IL10-modified MSCs in a mouse model of SCI. IL10-MSCs were generated and assessed for safety and efficacy, showing improved motor function recovery ...
KEY FINDING: IL10-MSC treatment markedly reinforced locomotor improvement, accompanied with decreased lesion volume, regeneration of axons, and preservation of neurons, compared with naïve unmodified MSCs.
The Journal of Spinal Cord Medicine, 2018 • January 1, 2018
SCI results in reduced metabolism, leading to adipose tissue accumulation and neurogenic obesity. Neurogenic obesity causes chronic, systemic inflammation through the overexpression of proinflammatory...
KEY FINDING: Obesity in SCI leads to chronic inflammation due to proinflammatory adipokines released from excess adipose tissue.
International Journal of Surgery, 2025 • June 24, 2024
This prospective, double-blind, randomized controlled study evaluated the safety and efficacy of intrawound vancomycin powder in preventing surgical site infections (SSIs) after posterior lumbar inter...
KEY FINDING: The study found an 87.5% decrease in the surgical site infection (SSI) rate in the vancomycin group compared to the control group.
Cellular & Molecular Biology Letters, 2022 • September 2, 2022
This study investigates the evolutionary dynamics and function of progranulins (PGRNs) in lampreys, primitive vertebrates known for their regenerative abilities. Four genes encoding PGRNs were identif...
KEY FINDING: Four PGRN genes were identified in lampreys: one long form (Lr-PGRN-L) and three short forms (Lr-PGRN-S1, Lr-PGRN-S2, and Lr-PGRN-S3).
JOURNAL OF NEUROTRAUMA, 2012 • May 20, 2012
This study investigates the effects of mesenchymal stem cell (MSC) transplantation on macrophage activation and functional recovery in rats after spinal cord injury (SCI). The results demonstrate that...
KEY FINDING: Transplanted MSCs migrate to the injury site but do not turn into nerve or glial cells.