Immunology Research

KEY FINDING: PHI significantly inhibited the inflammatory response and neuronal apoptosis while enhancing axonal regeneration and improving motor function recovery in vivo.

KEY FINDING: Linarin treatment significantly improved motor function in SCI mice, as evidenced by higher BMS scores, better performance in the inclined plane test, and improved footprint analysis scores.

KEY FINDING: Exercise training inhibits microglial activation and synaptic phagocytosis in the striatum of PD mice.

KEY FINDING: miR-19a and miR-19b up- and downregulate different genes, leading to distinct inflammatory responses in microglia.

KEY FINDING: E. coli was the most common microorganism found in both UTIs and UTCs.

KEY FINDING: Tim-3 is highly expressed in spinal cord tissues of SCIRI rats. Blocking Tim-3 attenuated SCIRI-induced pathological injury, neuronal apoptosis, neuroinflammation, and microglia activation (M1 polarization).

KEY FINDING: DF treatment significantly increased the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) in CCI rats, indicating its analgesic effect.

KEY FINDING: Tomatidine promotes neuronal damage recovery and reduces histopathological changes in spinal cord tissues and LPS-induced PC-12 cells.

KEY FINDING: Trehalose enhances macrophage phagocytosis and clearance of myelin debris in a dose-dependent manner in vitro, with an optimal concentration of 20 mM.

KEY FINDING: Spinal cord injury (SCI) at the T9 level amplifies lung inflammation in mice following exposure to lipopolysaccharide (LPS), as evidenced by increased pro-inflammatory gene expression and cytokine release.