Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 791-800 of 850 results
Biomaterials, 2012 • January 1, 2012
This study explores the use of glycomimetic-functionalized collagen as a biomaterial for neural tissue engineering. Type I collagen scaffolds were functionalized with peptide mimics of polysialic acid...
KEY FINDING: Grafted HNK-1 encouraged motor neuron outgrowth, but not sensory neuron outgrowth, maintaining modality-specific responses.
Journal of Extracellular Vesicles, 2021 • September 23, 2021
This study introduces a QCM-I and AFM-based protocol for characterizing EVs by elasticity and surface markers, tailored for reproducibility and integration in existing labs. The method utilizes specif...
KEY FINDING: The study established QCM as a sensitive label-free method for characterizing clinically approved umbilical cord MSC-EVs, detecting EVs via specific EV and MSC markers.
Oxidative Medicine and Cellular Longevity, 2023 • May 25, 2023
This review highlights the ability of C-dots to function as anti-inflammatory agents targeting inflammation-associated diseases, demonstrating their exceptional potential as nanomedicines. C-dots have...
KEY FINDING: C-dots exhibit anti-inflammatory effects in models of LPS-induced inflammation, gout, spinal cord injury, wound healing, and other diseases.
Journal of Biomedical Optics, 2024 • March 19, 2024
This paper introduces the photoacoustic differential attenuation spectrum (PA-DAS) method to study the attenuation characteristics of cancellous bone for osteoporosis diagnosis. The method modifies Bi...
KEY FINDING: The photoacoustic differential attenuation spectrum (PA-DAS) method can effectively differentiate osteoporotic bone from healthy bone.
Biomaterials, 2014 • September 1, 2014
The study investigates the distinct roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted intracortical microelectrodes using a bone marrow chimera m...
KEY FINDING: There was no correlation between microglia populations and neuron populations at the microelectrode-tissue interface.
Adv Mater, 2019 • January 1, 2019
Advances in biomaterial synthesis, stem cell biology, bioimaging, microsurgery, and microscale technologies have made minimally invasive therapeutics a viable tool in regenerative medicine. Therapeuti...
KEY FINDING: Needles have been utilized to deliver cell-laden biomaterials into the body.
Advanced Science, 2024 • December 25, 2023
The study developed LMGDNPs, injectable hydrogel microspheres, to address the nutrient imbalance and harsh microenvironment in degenerated intervertebral discs (IVD). LMGDNPs promoted cell survival an...
KEY FINDING: LMGDNPs showed a delayed release of lactate oxidase (LOX) and effectively consumed lactate, a harmful metabolic byproduct, creating a more favorable environment for cells.
Journal of Nanobiotechnology, 2022 • December 28, 2022
The study developed CaO2@mPDA-SH nanoparticles that can regulate the tumor microenvironment by consuming lactic acid and alleviating hypoxia. The nanoparticles promote immune responses, inhibit angio...
KEY FINDING: CaO2@mPDA-SH nanoparticles can dually regulate tumor hypoxia and lactic acid metabolism.
Neural Regen Res, 2019 • August 1, 2019
The review discusses the role and prospects of regenerative biomaterials in repairing spinal cord injuries (SCI). It highlights how biomaterials can address axonal junction defects and inhibitory envi...
KEY FINDING: Natural materials like collagen, chitosan, and hyaluronic acid offer good biocompatibility and biological functionality in SCI repair.
J Control Release, 2013 • September 28, 2013
The study investigates the use of polysaccharide-modified PLG scaffolds for controlled lentivirus delivery to enhance tissue regeneration, particularly in spinal cord injuries. Surface modification wi...
KEY FINDING: Chitosan and heparin modification of PLG scaffolds significantly enhanced lentivirus association and transduction efficiency in vitro compared to hyaluronan and control scaffolds.